Results 61 to 70 of about 647,566 (296)

Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives [PDF]

Exploration of Drug Science
Aim: To expand the understanding of the structure-activity relationship within a family of amino acid-derived β-lactam TRPM8 (transient receptor potential melastatin channel, subtype 8) antagonists, this work investigated both the configuration ...
Cristina Martín-Escura, Maria Angeles Bonache, Alicia Medina-Peris, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz   +6 more
doaj   +1 more source

Immunomodulatory responses of toll like receptors against 2019nCoV

Russian Open Medical Journal, 2021
The present review discusses the immune signals via toll like receptors (TLRs) against 2019nCoV. We researched using different database, up to June 18th, 2020. All the included articles were published in English language. The outcome of this review, that
Amany Sayed Maghraby
doaj   +1 more source

A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro" [PDF]

, 2016
The progression of prostate cancer (PC) to a metastatic hormone refractory disease is the major contributor to the overall cancer mortality in men, mainly because the conventional therapies are generally ineffective at this stage. Thus, other therapeutic
Bolchi, Cristiano, Castelnovo, Luca, Colciago, Alessandra, FERRI, NICOLA, Fumagalli, Laura, Mornati, Ornella, Negri Cesi, Paola, Pallavicini, Marco, Valoti, Ermanno   +8 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Agonists, Antagonists and Receptors of Somatostatin: Pathophysiological and Therapeutical Implications in Neoplasias

Current Issues in Molecular Biology
Somatostatin is a peptide that plays a variety of roles such as neurotransmitter and endocrine regulator; its actions as a cell regulator in various tissues of the human body are represented mainly by inhibitory effects, and it shows potent activity ...
Argyrios Periferakis, Georgios Tsigas, Aristodemos-Theodoros Periferakis, Carla Mihaela Tone, Daria Alexandra Hemes, Konstantinos Periferakis, Lamprini Troumpata, Ioana Anca Badarau, Cristian Scheau, Ana Caruntu, Ilinca Savulescu-Fiedler, Constantin Caruntu, Andreea-Elena Scheau   +12 more
doaj   +1 more source

Bioprospecção de isolados de Trichoderma spp. para o controle de Rhizoctonia solani na produção de mudas de pepino Bioprospection of Trichoderma spp. isolates to control Rhizoctonia solani on cucumber seedling production

Pesquisa Agropecuária Brasileira, 2009
O objetivo deste trabalho foi selecionar e identificar isolados de Trichoderma spp. para o controle do tombamento causado por Rhizoctonia solani (AG-4) em plântulas de pepino (Cucumis sativus L.), além de avaliar o efeito de concentrações crescentes e de
Cleusa Maria Mantovanello Lucon, Claudia Mitsue Koike, Alice Ishida Ishikawa, Flávia Rodrigues Alves Patrício, Ricardo Harakava   +4 more
doaj   +1 more source

How the Visual Design of Video Game Antagonists Affects Perception of Morality

Frontiers in Computer Science, 2021
The visual design of antagonists—typically thought of as “bad guys”—is crucial for game design. Antagonists are key to providing the backdrop to a game's setting and motivating a player's actions.
Reyhan Pradantyo, Max V. Birk, Scott Bateman   +2 more
doaj   +1 more source

Platelet lysate-derived neuropeptide y influences migration and angiogenesis of human adipose tissue-derived stromal cells [PDF]

, 2018
Neuropeptide Y (NPY), a powerful neurotransmitter of the central nervous system, is a key regulator of angiogenesis and biology of adipose depots. Intriguingly, its peripheral vascular and angiogenic powerful activity is strictly associated to platelets,
Bordin, Antonella, Businaro, Rita, Capoano, Raffaele, Corsi, Mariangela, DE FALCO, Elena, Frati, Giacomo, Pagano, Francesca, Petrozza, Vincenzo, Pierangelatotta,, Procaccini, Eugenio, Salvati, Bruno, Scaccia, Eleonora, Siciliano, Camilla, Teresa Vietri, Maria   +13 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents [PDF]

Royal Society Open Science, 2018
Metastatic cancer is considered a fatal progression of cancer worldwide. It has been shown that a key player in this scenario is the CXC chemokine receptor 2 (CXCR2).
Jinxin Che, Zhilong Wang, Haichao Sheng, Feng Huang, Xiaowu Dong, Youhong Hu, Xin Xie, Yongzhou Hu   +7 more
doaj   +1 more source