Results 71 to 80 of about 647,566 (296)

ACTH Antagonists [PDF]

Proceedings of the National Academy of Sciences, 1974
Structural modifications within the active site of the ACTH molecule have produced analogs that inhibit the hormone sensitive adenylate cyclase system of bovine adrenal cortical plasma membranes. It is demonstrated that the tryptophan residue of the ACTH molecule is essential for stimulation of the enzyme.
K, Hofmann, J A, Montibeller, F M, Finn
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Design and Evaluation of Heterobivalent PAR1–PAR2 Ligands as Antagonists of Calcium Mobilization [PDF]

, 2019
A novel class of bivalent ligands targeting putative protease-activated receptor (PAR) heteromers has been prepared based upon reported antagonists for the subtypes PAR1 and PAR2.
Arnold, Leggy A., Dockendorff, Chris, Gandhi, Disha M., Kodall, Revathi, Majewski, Mark W., Rosas, Ricardo, Jr.   +5 more
core   +1 more source

The novel CXCR4 antagonist POL5551 mobilizes hematopoietic stem and progenitor cells with greater efficiency than Plerixafor [PDF]

, 2013
Mobilized blood has supplanted bone marrow (BM) as the primary source of hematopoietic stem cells for autologous and allogeneic stem cell transplantation.
A Dar, A D’Souza, A Foudi, A Nagler, A Peled, AM Greenbaum, AW Roberts, B Nervi, CC Bleul, CL Semerad, D Obrecht, DE Harrison, F Ferraro, F Liu, GA Velders, GL Uy, H Balaguer, H Bonig, H Bonig, H Bonig, H Bonig, H Bonig, HE Broxmeyer, IG Winkler, JP Levesque, JP Levesque, K Balabanian, MA Pulsipher, MA Ryan, MJ Christopher, MM Mueller, MP Rettig, MZ Ratajczak, N Amariglio, P Anderlini, P Anderlini, P Anderlini, S Akizuki, SJ DeMarco, SJ Szilvassy, SM Devine, SP Fricker, T Lapidot, TA Lane, V Saini, WC Liles, Y Katayama, Y Takamatsu   +47 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Altered postural control strategies in people with chronic low back pain: an overactive latissimus dorsi? [PDF]

Romanian Journal of Physical Therapy, 2021
Purpose: The aim of the research is to examine the possible alterations in the functioning of muscles in chronic low back pain (LBP). Method: In this prospective study 35 people were selected into LBP and control (C) groups after they had completed the
Regina FINTA, Peter KATONA, Edit NAGY
doaj  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Indomethacin-antihistamine combination for gastric ulceration control [PDF]

, 1981
An anti-inflammatory and analgesic composition containing indomethacin and an H sub 1 or an H sub 2 histamine receptor antagonist in an amount sufficient to reduce gastric distress caused by the indomethacin is described.
Brown, P. A., Danellis, J. V.
core   +1 more source

Correlation between centrality metrics and their application to the opinion model [PDF]

, 2014
In recent decades, a number of centrality metrics describing network properties of nodes have been proposed to rank the importance of nodes. In order to understand the correlations between centrality metrics and to approximate a high-complexity ...
A. Jamakovic, A.-L. Barabási, B. Mullen, B. Pittel, C. Castellano, C. Li, C.H. Comin, Cong Li, E. Estrada, H. Eugene Stanley, H. Wang, H.-W. Ma, Huijuan Wang, I.J. Farkas, J. Borge-Holthoefer, J. Shao, K.E. Joyce, L. Costa da F., L.C. Freeman, M. Faloutsos, M. Kitsak, M. Krivelevich, M.E.J. Newman, M.P. Joy, N.E. Friedkin, P. Erdős, P.-J. Kim, Piet Van Mieghem, Q. Li, Q. Li, Qian Li, R. Cohen, R. Pastor-Satorras, S. Boccaletti, S. Galam, S. Trajanovski, S.B. Seidman, S.H. Strogatz, S.P. Borgatti, V. Batagelj   +39 more
core   +2 more sources

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source