Results 211 to 220 of about 164,065 (276)

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Clarifying social undermining in nursing: a concept analysis. [PDF]

BMC Nurs
Ghasemi H, Etedali M, Alimohammadi N, Shahriari M.   +3 more
europepmc   +1 more source

Climate Change is Rewriting the Hydroclimatic Operating Envelope of Mines

Advanced Science, EarlyView.
Climate change is shown to shift the hydroclimatic operating envelope of mines: 16.2% of represented mine locations have already changed Köppen subtype, rising to 42.5% by late century under SSP5‐8.5. Divergent water trajectories are filtered through geology, infrastructure and lifecycle stage, indicating that adaptation requires monitored, scenario ...
Haoxuan Yu, Izni Zahidi, Chow Ming Fai, Jilong Pan   +3 more
wiley   +1 more source

Decoding the Factors Influencing Parental Vaccine Decision-Making: Insights from Saudi Arabia on COVID-19 Vaccination for Children-Lessons for Future Pandemics. [PDF]

Vaccines (Basel)
Kassem L, Anaam MS, Aldaiji FA, Alqarzaee FA, Almogarri FA, Almansour HA, Almutairi NA, Elnaem MH, Almutairi H, Alsohaim SI, Siddeeg K, Altowayan WM.   +11 more
europepmc   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Dimensions of artificial intelligence anxiety among employees in the age of innovation: a systematic review. [PDF]

Front Psychol
Alsudays S.
europepmc   +1 more source

Eco‐Friendly Laser‐Induced Graphene/Perovskite Hybrids for Eco‐Friendly Photodetectors

Advanced Electronic Materials, EarlyView.
A sustainable paper‐based photodetector was developed by combining laser‐induced graphene (LIG) with MAPbI3 perovskite. Compared with pure LIG devices, the hybrid photodetector exhibited nearly 10‐fold higher responsivity and 7‐fold greater detectivity while maintaining stable performance after 1000 bending cycles, demonstrating its potential for ...
Ya‐Yun Huang, Wei‐Hua Hsu, Bo‐Hua Chiou, Wei‐Chen Tu   +3 more
wiley   +1 more source

Family Empowerment for Stunting Prevention in Children Aged 0-2 Years: A Concept Analysis. [PDF]

J Multidiscip Healthc
Sutini T, Rakhmawati W, Mediani HS, Permatasari TAE.   +3 more
europepmc   +1 more source

"I Wish I Never Got on That Roller Coaster": A Qualitative Investigation of the Emotional Antecedents and Correlates of Loss of Control Eating in Black Youth Living in Larger Bodies. [PDF]

Int J Eat Disord
Egbert AH, Mullings A, Schram S, Goldschmidt AB, Fitzpatrick BL, Goldberg J.   +5 more
europepmc   +1 more source