Results 41 to 50 of about 123,516 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Young adults’ perceived future employability: antecedents and consequences

, 2020
Optimistic perception of one’s future employability is critical for young people, being linked to motivation, behaviours, and well-being. We tested some antecedents and outcomes to perceived future employability (PFE) and their mediation effects ...
Creed, PA, Glendon, A, Gunawan, W
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Presenting the model of antecedents affecting moral-emotional acting in education [PDF]

مدیریت و چشم انداز آموزش
The aim of the current research is to identify and rank the antecedents affecting moral-emotional acting in education. This research was applicable in terms of its purpose, and was carried out with a quantitative approach with an exploratory design.
arefeh kazemi malekmahmoudi, negin jabbari, kiomars niaz azari   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Antecedents of purpose in life: Evidence from a lagged exposure-wide analysis

Cogent Psychology, 2020
Potential antecedents to having a sense of purpose in life remain understudied. As researchers begin contemplating purpose as a promising target of public health intervention, it is critical to identify its antecedents.
Ying Chen, Eric S. Kim, Alexandra E. Shields, Tyler J. VanderWeele   +3 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Antecedents and consequences of panic buying: The case of COVID‐19

, 2020
Panic buying emerged as a significant phenomenon during the COVID‐19 pandemic. This study draws on the scarcity principle, crowd psychology, and contagion theory to investigate the antecedents and consequences of panic buying. The antecedents included in
Thaichon, Park, Quach, Sara, Prentice, Catherine   +2 more
core   +2 more sources

Relacions públiques pioneres a Espanya. Alguns precedents a la primera meitat del segle XX i passos preliminars de la nova professió

Anàlisi: Quaderns de Comunicació i Cultura, 2012
Aquest article presenta els resultats d'una investigació duta a terme per identificar alguns antecedents a Espanya de l'activitat que coneixem com a relacions públiques en el període comprès entre finals del segle XIX i la primera meitat del segle XX. Es
Enrique Armendáriz
doaj   +1 more source