Results 51 to 60 of about 867,291 (286)

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Depression remains a neglected public health problem among pregnant women in Northwest Ethiopia

Archives of Public Health, 2021
Background Antenatal depression is highly prevalent but a neglected public health problem in low income countries. It has serious effects on the general health of women, birth outcomes and child health.
Getnet Mihretie Beyene, Telake Azale, Kassahun Alemu Gelaye, Tadesse Awoke Ayele   +3 more
doaj   +1 more source

Offspring of parents with recurrent depression: which features of parent depression index risk for offspring psychopathology? [PDF]

, 2012
Background: Parental depression is associated with an increased risk of psychiatric disorder in offspring, although outcomes vary. At present relatively little is known about how differences in episode timing, severity, and course of recurrentdepression ...
Sellers, R., Frances Rice (11378531), Sellers, Ruth, Harold, G.T., Potter, Robert, Stephan Collishaw, Nicholas Craddock (613070), Anita Thapar (766569), Robert Potter (3455717), Daniel Smith (6120), Daniel Smith, Anita Thapar, Gordon T. Harold, Craddock, Nicholas John, Stephan Collishaw (766570), Becky Mars, Smith, Daniel, Thapar, Anita, Ruth Sellers (4465924), Ruth Sellers, Harold, Gordon Thomas, Rice, Frances, Thapar, A., Collishaw, S., Thapar, Ajay Kumar, Thapar, Ajay, Robert Potter, Craddock, N., Ajay Thapar, Ajay Thapar (16221035), Collishaw, Stephan, Becky Mars (766567), Gordon Harold (4464610), Potter, R., Craddock, Nicholas, Frances Rice, Rice, F., Harold, Gordon T, Mars, Becky, Nicholas Craddock, Mars, B., Smith, Daniel J., Smith, D.   +42 more
core   +1 more source

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert, Gudny Anna Arnadottir, Laura Bedinger, Nicola Brunetti‐Pierri, Jennifer Cech, Xin Chen, Yanmin Chen, Erika Chick, Sarah Dyack, Madeleine Franchi, Tanja Frey, David Genevieve, Ian Glass, Jorge Granadillo, Kelly A. Keener, Sara B. MacKay, Paige McDunnah, Vinod K. Misra, Kristin G. Monaghan, Sureni V. Mullegama, Cristina Peduto, Leia Peterman‐Prather, Anita Rauch, Cherith Somerville, Kari Stefansson, Katharina Steindl, Patrick Sulem, Telma Sulem, Pamela Trapane, Roberta Zeuli, Samuel Zinner, Kosuke Izumi   +31 more
wiley   +1 more source

Maternal Child Attachment and Perinatal Depression [PDF]

, 2012
Traditionally, pregnancy has been thought of as a period of well-being and happiness. The pregnancy state itself has been thought to protect women from depression. However, women of child-bearing age frequently suffer from major depression. Approximately
ROSSI, LAVINIA
core  

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

The Association Between the Use of Antenatal Care Smartphone Apps in Pregnant Women and Antenatal Depression: Cross-Sectional Study

JMIR mHealth and uHealth, 2018
BackgroundAntenatal care smartphone apps are increasingly used by pregnant women, but studies on their use and impact are scarce. ObjectiveThis study investigates the use of antenatal care apps in pregnant women and explores the association ...
Mo, Yushi, Gong, Wenjie, Wang, Joyce, Sheng, Xiaoqi, Xu, Dong R   +4 more
doaj   +1 more source

Antenatal depression and offspring health outcomes

Obstetric Medicine, 2019
Background Depression is the most common mental disorder during pregnancy, with prevalence rates between 4% and 20%. The objective of this review was to synthesize the literature on the association between antenatal depression and offspring birth outcomes, as well as developmental, behavioral, and psychiatric outcomes.
Alexandra Smith, Jasna Twynstra, Jamie A Seabrook   +2 more
openaire   +4 more sources

Early stages of tooth development in the harbor porpoise Phocoena phocoena

The Anatomical Record, EarlyView.
Abstract Here we describe the stages of tooth development in toothed whales on the basis of the harbor porpoise (Phocoena phocoena). The aim of the study was to find out whether these stages are identical to those of other mammals analyzed so far although toothed whales are homodont and monophyodont.
Lasse M. Mathes, Lennart Müller‐Thomsen, Stefan Huggenberger   +2 more
wiley   +1 more source

Antenatal Depression and STAND

A presentation about our on-going research into antenatal depression and the collaboration of a number of different ...
CUST, Fiona, CARTER, Ruth, BOATH, Elizabeth   +2 more
core   +7 more sources