Results 191 to 200 of about 1,418,276 (316)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

CHARACTERISTICS AND VITREORETINAL MANAGEMENT OF RETINAL DETACHMENT IN EYES AFTER PENETRATING KERATOPLASTY IN a 10-YEAR STUDY. [PDF]

Retina
Hao Y, Fang Y, Zheng P, Jie Y, Li Q.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Segmentation Errors of Two Modern Biometers in 100 Eyes with Phakic Intraocular Lenses. [PDF]

Clin Ophthalmol
Monteiro S, Marques JH, Abreu AC, Menéres P, Melo Beirão J, Pinto MDCB.   +5 more
europepmc   +1 more source

The Anterior Choroidal Artery [PDF]

Acta Radiologica, 1956
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Early-Onset Myocardial Infarction in a 13-Year-Old With Homozygous Familial Hypercholesterolemia Managed by PCI. [PDF]

JACC Case Rep
Siddiqui FI, Ghaffar A, Rehman IU, Zaffar MZ, Hassan A, Mehmood Y, Adhikari S, Noor S.   +7 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Aesthetic Rehabilitation of Anterior Teeth With Molar Incisor Hypomineralization-A Case Report of a New Approach to Selective Removal. [PDF]

Clin Case Rep
Doueiri MS, Ratnapreya S, Frankenberger R.   +2 more
europepmc   +1 more source

Anterior intermeniscal ligament: an anatomic study of its insertion pattern in Ghanaians

, 2014
Ato Ampomah BROWN
openalex   +1 more source