Results 171 to 180 of about 42,452 (222)

Intramedullary nail design for Thais with novel multi-femur shape optimization approach. [PDF]

Sci Rep
Sayabut D, Virulsri C, Tangpornprasert P.   +2 more
europepmc   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Virtual Reality Mindfulness Meditation for Patients After Anterior Cruciate Ligament Reconstruction: Protocol for the Development of a National Institutes of Health Stage 1 Behavioral Intervention. [PDF]

JMIR Res Protoc
Baez S, Marmura H, Pietrosimone B, Moser J.   +3 more
europepmc   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Beyond Mean HU: Spatial Radiodensity Mapping of the Human Hyoid as a Baseline for Morphological and Biomechanical Investigation. [PDF]

Biology (Basel)
Morávek A, Martinková K, Henyš P, Velemínská J, Hammer N, Kuchař M.   +5 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Transperineal ultrasonography assisted examination improves maternal and neonatal outcomes of forceps delivery: a propensity-score-matched analysis. [PDF]

Sci Rep
Hashiramoto S, Takita H, Arakaki T, Yamashita Y, Kaneko M, Matsuoka R, Sekizawa A.   +6 more
europepmc   +1 more source

Efficient Polarization‐Entangled Photon‐Pair Generation by a Fiber‐In‐Line van der Waals Material

Advanced Science, EarlyView.
Telecom‐wavelength polarization‐entangled photon pairs are generated in a van der Waals‐material‐integrated all‐fiber device via spontaneous parametric down‐conversion. The demonstrated fiberized quantum light source bridges emerging 2D nonlinear materials and practical quantum photonic systems, opening new opportunities for scalable fiber‐based ...
Jungseok Choi, Seongju Ha, Seungjae Lim, Joohyeon Ahn, Jaekyoung Kim, Jong Hyuk Yim, Nam Hun Park, Youngdong Yoo, Jae‐Ung Lee, Hee Su Park, Sang Min Lee, Dong‐Il Yeom   +11 more
wiley   +1 more source