Results 101 to 110 of about 12,916,357 (311)

Anterior approach for difficult major right hepatectomy

open access: yes, 1996
In selected patients with huge right hepatic tumors that had infiltrated the surrounding structures, injudicious mobilization of the liver before transection, as in the conventional manner, may result in excessive bleeding, prolonged ischemia from ...
Lo, CM   +4 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Effectiveness of various anterior noncontiguous cervical spine surgeries for treatment of noncontiguous cervical degenerative disk disease: a network meta-analysis [PDF]

open access: yesAsian Spine Journal
We conducted a systematic review and network meta-analysis (NMA) to compare the effectiveness of noncontiguous anterior cervical surgical techniques for noncontiguous cervical degenerative disk disease (CDDD) in terms of clinical outcomes.
Anthony N. Baumann   +8 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Anterior approach during hepatectomy

open access: yes, 2013
The anterior-approach right hepatectomy was introduced by Kazue Ozawa in 1992. It is particularly suitable for treating large right-liver tumors.
Fan, ST
core  

The mini-anterior approach: Optimizes total hip arthroplasty outcome—Affirms

open access: yes, 2015
The direct anterior approach for total hip arthroplasty has gained popularity in recent years and evidence to support this method continues to grow. Through our own research, we have noted several advantages compared to the posterior approach.
Rodriguez, J. A., Jahng, K. H.
core   +1 more source

Evolution of Thoracic Disc Herniation Surgery: Future Perspectives from a Systematic Review and Meta-Analysis

open access: yesBrain Sciences
Background: The neurosurgical treatment of thoracic disc herniation (TDH) has undergone dramatic changes over the years in terms of surgical approaches and intraoperative technological tools.
Giuseppe Corazzelli   +12 more
doaj   +1 more source

Self Manipulated Cervical Spine Leads to Posterior Disc Herniation and Spinal Stenosis

open access: yesBrain Sciences, 2019
The authors report a case in which a 38-year-old male who presented himself to the emergency department with a chief complaint of cervical neck pain and paresthesia radiating from the right pectoral region down his distal right arm following self ...
Wyatt McGilvery   +3 more
doaj   +1 more source

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