Results 131 to 140 of about 12,916,357 (311)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Anterior-posterior radiograph ankle arthrodesis.

, 2016
Anterior to posterior ankle radiograph with the measurement of the frontal tibiotalar angle (FTTA). The FTTA is the superomedial angle between the two axes A and B. A = longitudinal axis of the tibia, created by connecting two points in the middle of the
Johannes Holinka (2636257), Peter Bock (361592), Axel Hugo Wanivenhaus (2636263), Elena Nemecek (2636260), Reinhard Schuh (2636266), Reinhard Windhager (310422), Madeleine Willegger (2636269)   +6 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Anterior Approach in Total Hip Replacement

, 2017
In total hip replacement, the anterior approach is intermuscular and internervous and allows the surgeon to reach the capsule without muscle detachment. Advantages include faster recovery and excellent functional outcome as well as reduced postoperative ...
Giuseppe Tedesco, TERRANDO, SILVIO, CADOSSI, MATTEO, Cesare Faldini, MAZZOTTI, ANTONIO, SAMBRI, ANDREA, Antonio Mazzotti, Andrea Sambri, FALDINI, CESARE, Matteo Cadossi, TEDESCO, GIUSEPPE, Silvio Terrando   +11 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Laparoscopic left and right adrenalectomy from an anterior approach – is there any difference? Outcomes in 176 consecutive patients

, 2016
Introduction : Traditionally, in open surgery, right adrenalectomy is considered technically more demanding than its left-sided counterpart. This belief is supposed to be attributable mainly to different anatomic characteristics of the adrenal veins ...
Lukas Kokorak, Peter Vladovic, Lubomir Marko, Marek Soltes   +3 more
core   +1 more source

Management Considerations for Cervical Corpectomy: Updated Indications and Future Directions

Life
Together, lower back and neck pain are among the leading causes of acquired disability worldwide and have experienced a marked increase over the past 25 years. Paralleled with the increasing aging population and the rise in chronic disease, this trend is
Marco Foreman, Devon Foster, Wiley Gillam, Christopher Ciesla, Chris Lamprecht, Brandon Lucke-Wold   +5 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

A Conservative Approach for Restoring Anterior Guidance: A Case Report

, 2011
One of the most common dental problems in today's clinics is tooth wear, specifically when related to bruxism. In such cases, the esthetics of anterior teeth may be compromised when excessive wear to the incisal surfaces occurs.
ADILSON YOSHIO FURUSE, Pizzatto, Eduardo, Mondelli, Jose, JUAN CARLOS PONTONS-MELO, EDUARDO PIZZATTO, Carlos Pontons-Melo, Juan, Furuse, Adilson Yoshio, JOSÉ MONDELLI   +7 more
core   +1 more source

Delayed presentation of lower cervical facet dislocations: What to learn from past reports?

SICOT-J
Delayed presentation of lower cervical facet dislocations is uncommon, and there is no standardized way to approach these neglected injuries. The literature on neglected lower cervical facet dislocations is limited to case reports and few retrospective ...
Nkurikiyumukiza Laurent, Buteera Alex Mathias, El-Sharkawi Mohammad Mostafa   +2 more
doaj   +1 more source