Results 131 to 140 of about 13,480 (263)

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Long-Term Stability and Safety of Orthognathic-Orthodontic Correction for Skeletal Anterior Open Bite: A Systematic Review and Evidence Appraisal. [PDF]

Cureus
Obeisi AH, Alanazi MM, Natto SB, Alsalmi HA, Alzahrani AA, Alotaibi RA, Aljari AA, Alzahrani SB, Alamri FB, Mohammed Alghamdi AF, Katib HS.   +10 more
europepmc   +1 more source

Tooth size discrepancy in orthodontic patients with skeletal anterior open bite. [PDF]

Clin Exp Dent Res, 2022
Al Maaitah EF, Al-Madani N, Abu Alhaija ES.   +2 more
europepmc   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Scoping Review-The Effectiveness of Clear Aligners in the Management of Anterior Open Bite in Adult Patients. [PDF]

Medicina (Kaunas)
Olteanu ND, Romanec C, Cernei ER, Karvelas N, Nastri L, Zetu IN.   +5 more
europepmc   +1 more source

Orthodontic treatment of children with anterior open bite and posterior crossbite: An analysis of the stomatognathic system. [PDF]

J Oral Biol Craniofac Res, 2023
Gonçalves LMN, Palinkas M, Regalo IH, Gonçalves PN, de Vasconcelos PB, Matsumoto MAN, Siéssere S, Regalo SCH.   +7 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Correction of Anterior Open Bite Using Temporary Anchorage Devices: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Burgos-Lancero P, Ibor-Miguel M, Marqués-Martínez L, Boo-Gordillo P, García-Miralles E, Guinot-Barona C.   +5 more
europepmc   +1 more source

Correction of anterior open bite of varying severity using clear aligner therapy-A case series. [PDF]

Clin Case Rep, 2022
Sabouni W, Venugopal A, Adel SM, Vaid N.
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source