EpCAM Is a Surface Marker for Enriching Anterior Pituitary Cells From Human Hypothalamic-Pituitary Organoids [PDF]
Human stem cell-derived organoid culture enables the in vitro analysis of the cellular function in three-dimensional aggregates mimicking native organs, and also provides a valuable source of specific cell types in the human body.
Yu Kodani+13 more
doaj +2 more sources
Dysregulated zinc homeostasis and microadenomas in the anterior pituitary: pathological insights into suicide risk [PDF]
BackgroundSuicide is a significant public health problem influenced by various risk factors, including dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis.
Hiram Tendilla-Beltrán+8 more
doaj +2 more sources
An Exploration of Non-Coding RNAs in Extracellular Vesicles Delivered by Swine Anterior Pituitary [PDF]
Extracellular vesicles are lipid bilayer-delimited particles carrying proteins, lipids, and small RNAs. Previous studies have demonstrated that they had regulatory functions both physiologically and pathologically. However, information remains inadequate
Jiali Xiong+8 more
doaj +2 more sources
Effect of enhanced plane of nutrition in early life on the transcriptome and proteome of the anterior pituitary gland in Angus heifer calves [PDF]
Background Enhanced nutrition during the early calfhood period has been shown to lead to earlier pubertal development in heifer calves. This is of interest as earlier pubertal onset can subsequently facilitate earlier calving which can economically ...
Kate Keogh+2 more
doaj +2 more sources
Ultrastructural characteristics of the anterior pituitary gland of cattle in the definitive period of postnatal ontogenesis [PDF]
Today much attention is paid to the study of the pituitary ultrastructure of laboratory animals and humans. But there is not enough available literature to study the most important organ of internal secretion of productive animal.
Khasaev A.N.+4 more
doaj +1 more source
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis. [PDF]
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), a homologous peptide of HN expressed in several adult rat tissues, also has antiapoptotic action.
María Florencia Gottardo+9 more
doaj +1 more source
Background and Objectives: One type of immune-related adverse event caused by immune checkpoint inhibitors (ICIs) is pituitary-related adverse events.
Hiroki Asano+4 more
doaj +1 more source
Nitric Oxide Plays a Key Role in Ovariectomy-Induced Apoptosis in Anterior Pituitary: Interplay between Nitric Oxide Pathway and Estrogen. [PDF]
Changes in the estrogenic status produce deep changes in pituitary physiology, mainly because estrogens (E2) are one of the main regulators of pituitary cell population.
Sonia A Ronchetti+4 more
doaj +1 more source
Regulation of Prolactin Release at the End Stage of Chicken Embryogenesis
Difference of onset of increase of PRL content in the anterior pituitary gland and plasma PRL concentration during the late stage of chicken embryogenesis is well known. To investigate the disagreement, changes in PRL content and PRL mRNA levels, and the
Norio Kansaku+3 more
doaj +1 more source
The theory holds that the anterior pituitary in mammals receives humoral regulation. Previous studies have reported that the pars distalis of the anterior pituitary of several mammalian species contains substance P-, calcitonin gene-related peptide (CGRP)
Xiaohui Li+9 more
doaj +1 more source