Clinical Biology of the Pituitary Adenoma
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent and overwhelmingly benign, exhibiting a spectrum of diverse behaviors and
Shlomo Melmed+2 more
exaly +2 more sources
Anterior pituitary cell networks
Both endocrine and non-endocrine cells of the pituitary gland are organized into structural and functional networks which are formed during embryonic development but which may be modified throughout life. Structural mapping of the various endocrine cell types has highlighted the existence of distinct network motifs and relationships with the ...
P. Tissier+9 more
semanticscholar +5 more sources
Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary [PDF]
Transforming growth factor-alpha (TGF-alpha), a member of the epidermal growth factor (EGF) family, is produced within the mouse anterior pituitaries. However, the cell types of TGF-alpha-expressing cells and the physiological roles of TGF-a within mouse
Kakeya, Tomoshi+5 more
core +1 more source
Cell Type- and Sex-Dependent Transcriptome Profiles of Rat Anterior Pituitary Cells
Understanding the physiology and pathology of an organ composed of a variety of cell populations depends critically on genome-wide information on each cell type. Here, we report single-cell transcriptome profiling of over 6,800 freshly dispersed anterior
P. Fletcher+8 more
semanticscholar +1 more source
Functional heterogeneity among cell types in the normal pituitary gland and in human and rat pituitary tumors. [PDF]
Hormone secretion by the anterior pituitary gland is under control of hypothalamic regulatory factorsjhormones (see chapter I.l) and peripheral hormones.
Hofland, L.J. (Leo)
core +7 more sources
Genetic regulation of pituitary gland development in human and mouse [PDF]
Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s ...
Aarskog+321 more
core +2 more sources
Genetic background influences tumour development in heterozygous Men1 knockout mice [PDF]
Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder caused by MEN1 germline mutations, is characterised by parathyroid, pancreatic and pituitary tumours. MEN1 mutations also cause familial isolated primary hyperparathyroidism (FIHP)
Christie, Paul T.+11 more
core +2 more sources
Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells
Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and negative regulators are indispensable for homeostasis. For this reason, generating human anterior pituitary tissue that retains regulatory hormonal control in ...
Chikafumi Ozone+8 more
semanticscholar +1 more source
Intercellular Communication in the Anterior Pituitary* [PDF]
In addition to hypothalamic and feedback inputs, the secretory cells of the anterior pituitary are influenced by the activity of factors secreted within the gland. The list of putative intrapituitary factors has been expanding steadily over the past decade, although until recently much of the work was limited to descriptions of potential interactions ...
Jeffrey Schwartz, Jeffrey Schwartz
openaire +2 more sources
Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients [PDF]
Glucocorticoid hormones suppress the secretion of ACTH evoked by secretagogues such as CRF and arginine vasopressin. In this study, we investigated the effects of glucocorticoids on ACTH release induced by oxytocin (OT) and on intracellular free calcium ...
Dayanithi, G., Gratzl, Manfred, Link, H.
core +1 more source