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Gene Expression and the Physiological Role of Transforming Growth Factor-α in the Mouse Pituitary [PDF]

open access: yes, 2003
Transforming growth factor-alpha (TGF-alpha), a member of the epidermal growth factor (EGF) family, is produced within the mouse anterior pituitaries. However, the cell types of TGF-alpha-expressing cells and the physiological roles of TGF-a within mouse
Kakeya, Tomoshi   +5 more
core   +1 more source

A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development [PDF]

open access: yes, 2010
The mammalian pituitary gland originates from two separate germinal tissues during embryonic development. The anterior and intermediate lobes of the pituitary are derived from Rathke's pouch, a pocket formed by an invagination of the oral ectoderm.
Hermesz, Edit   +4 more
core   +1 more source

Intercellular Communication in the Anterior Pituitary* [PDF]

open access: yesEndocrine Reviews, 2000
In addition to hypothalamic and feedback inputs, the secretory cells of the anterior pituitary are influenced by the activity of factors secreted within the gland. The list of putative intrapituitary factors has been expanding steadily over the past decade, although until recently much of the work was limited to descriptions of potential interactions ...
Jeffrey Schwartz, Jeffrey Schwartz
openaire   +2 more sources

Genetic regulation of pituitary gland development in human and mouse [PDF]

open access: yes, 2009
Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s ...
Aarskog   +321 more
core   +2 more sources

Regulation of gonadotropin secretion and puberty onset by neuromedin U [PDF]

open access: yes, 2006
Neuromedin U (NMU), an anorexigenic peptide, was originally isolated from porcine spinal cord in 1985. As NMU is abundant in the anterior pituitary gland, we investigated the effects of NMU on gonadotropin secretion. Both NMU and its receptors, NMUR1 and
Fukue, Yoshihiko   +6 more
core   +1 more source

Functional heterogeneity among cell types in the normal pituitary gland and in human and rat pituitary tumors. [PDF]

open access: yes, 1989
Hormone secretion by the anterior pituitary gland is under control of hypothalamic regulatory factorsjhormones (see chapter I.l) and peripheral hormones.
Hofland, L.J. (Leo)
core   +7 more sources

Ancestral TSH mechanism signals summer in a photoperiodic mammal [PDF]

open access: yes, 2008
SummaryIn mammals, day-length-sensitive (photoperiodic) seasonal breeding cycles depend on the pineal hormone melatonin, which modulates secretion of reproductive hormones by the anterior pituitary gland [1].
Anderson   +41 more
core   +1 more source

Fgf10(+) progenitors give rise to the chick hypothalamus by rostral and caudal growth and differentiation [PDF]

open access: yes, 2017
Classical descriptions of the hypothalamus divide it into three rostro-caudal domains but little is known about their embryonic origins. To investigate this we performed targeted fate-mapping, molecular characterisation and cell cycle analyses in the ...
Aglyamova   +43 more
core   +1 more source

Genetic background influences tumour development in heterozygous Men1 knockout mice [PDF]

open access: yes, 2020
Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder caused by MEN1 germline mutations, is characterised by parathyroid, pancreatic and pituitary tumours. MEN1 mutations also cause familial isolated primary hyperparathyroidism (FIHP)
Christie, Paul T.   +11 more
core   +2 more sources

Augmented Hypothalamic Corticotrophin-Releasing Hormone mRNA and Corticosterone Responses to Stress in Adult Rats Exposed to Perinatal Hypoxia [PDF]

open access: yes, 2007
Stressful events before or just after parturition alter the subsequent phenotypical response to stress in a general process termed programming. Hypoxia during the period before and during parturition, and in the postnatal period, is one of the most ...
Cullinan, William E   +2 more
core   +2 more sources

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