Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source
Anthelmintic resistance of gastrointestinal cattle nematodes [PDF]
, 2013 Anthelmintic resistance of parasites in small ruminants, cattle and horses is increasing worldwide as a consequence of the over usage of the currently available products.
Claerebout, Edwin +2 more
core
In vivo nematicidal potential of camel milk on Heligmosomoides polygyrus gastro-intestinal nematode of rodents [PDF]
, 2018 Following our previous fi ndings on the in vitro anthelmintic effect of camel milk on Haemonchus contortus, the current study aimed at investigating its in vivo effect.
Abidi, A. +6 more
core +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Veterinary medicines, which reach the soil mostly through the application of contaminated manures, can affect beneficial soil microorganisms, such as nitrogen‐fixing rhizobia bacteria, which engage in important symbiotic associations with plants.
Polyxeni Gorgia +6 more
wiley +1 more source
Effect of bioactive compounds from Sainfoin (Onobrychis viciifolia Scop.) on the in vitro larval migration of Haemonchus contortus: role of tannins and flavonol glycosides [PDF]
, 2005 Anthelmintic bioactivity against gastrointestinal nematodes has been associated with leguminous forages supporting the hypothesis of a role of condensed tannins.
E., BARRAU +3 more
core +1 more source
Zoo Biology, EarlyView.ABSTRACT The emergence of anthelminthic resistance is a well‐documented phenomenon in livestock and companion animals. Given the scarcity of new antiparasitic drugs, the implementation of effective, holistic anthelminthic control strategies is critical to preserving the efficacy of existing treatments.
Stalder Sandro, Hatt Jean‐Michel
wiley +1 more source
Implementation of an extended ZINB model in the study of low levels of natural gastrointestinal nematode infections in adult sheep [PDF]
, 2016 Background: In this study, two traits related with resistance to gastrointestinal nematodes (GIN) were measured in 529 adult sheep: faecal egg count (FEC) and activity of immunoglobulin A in plasma (IgA).
Arranz, J.J. +6 more
core +2 more sources
Anthelmintic resistance in sheep nematodes in Australia: a compilation of recent test results
Australian Veterinary Journal, EarlyView.Objective The results of recent faecal egg count reduction tests (FECRTs) were collated to provide an indication of the prevalence and severity of anthelmintic resistance in sheep nematodes across Australia and of changes in comparison to earlier testing reports.
RB Besier, NM Rolls
wiley +1 more source
Sustainable control of cyathostomin infections in practice
Equine Veterinary Education, EarlyView.Summary Cyathostomins are the most prevalent helminths in horses and are found in nearly all grazing groups. These parasites have been shown to exhibit widespread anthelmintic resistance and can cause clinical disease, so they are a growing concern.
J. B. Matthews, T. S. Mair
wiley +1 more source
Nematode control in suckler beef cattle over their first two grazing seasons using a targeted selective treatment approach [PDF]
, 2015 peer-reviewedBackground With concerns over the development of anthelmintic resistance in cattle nematode populations, we must re-examine our approach to nematode control in cattle.
Barrett, Damien +6 more
core +1 more source