Results 41 to 50 of about 41,121 (207)
Clinical Pharmacology &Therapeutics, EarlyView.Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang +2 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz +5 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Anorexia nervosa (AN) is a serious illness in which more than half of all deaths are due to malnutrition. Critically low energy and protein intake are known causes of massive weight loss, whereas micronutrient deficiencies due to a low‐calorie food pattern remain poorly characterized in children with AN. Micronutrient deficiencies in
Zenaida Iordan +6 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective This Stage 2 Registered Report examined (1) the main effects and interaction of within‐person daily associations between ovarian hormones (i.e., estrogen, progesterone) and loss of control eating (LOCE), and (2) the within‐person mediating roles of food‐related reward anticipation and response inhibition. Methods Adolescent girls (n =
Tyler B. Mason +4 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective To update the evidence regarding the diagnostic accuracy of eating disorder (ED) questionnaires in adolescents and adults with higher weight. Method Five databases were systematically searched from 2020 to November 2025 (CRD420251186115).
Eve T. House +6 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective This systematic review evaluated the feasibility, efficacy, adherence, and methodological quality of ecological momentary intervention (EMI)–based treatments for individuals with diagnosed eating disorders (EDs) and/or obesity. Method Eight electronic databases were systematically searched from inception to January 2026.
Wenlu Mao +4 more
wiley +1 more source
Changes in Eating Disorder Symptoms in Perinatal US Military Servicewomen
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective The perinatal period is a window of exacerbated vulnerability for eating disorder symptoms. Moreover, US military servicewomen represent a population at increased risk for eating disorder psychopathology relative to civilians.
Katherine A. Thompson +10 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objectives We compared two measures of Avoidant/Restrictive Food Intake Disorder (ARFID)—the NIAS and the PARDI‐AR‐Q to determine which demonstrates better psychometric and clinical utility. Methods The study was pre‐registered (OSF; DOI 10.17605/OSF.IO/N8WBF). Participants (aged ≥ 18 years, BMI > 18.5) were recruited via Prolific and screened
Rebecca Nicholls‐Clow +2 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1141-1150, April 2025.Abstract Background Arterial stiffness is a crucial factor in determining an increase in systolic blood pressure and pulse pressure and can also predict the development of cardiovascular disease (CVD). The purpose of this study was to examine the relationship between arterial stiffness and future CVD.
Susan Darroudi +10 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1326-1335, April 2025.Abstract Aims Amyloid cardiomyopathy is caused by the deposition of light chain (AL) or transthyretin amyloid (ATTR) fibrils, that leads to a restrictive cardiomyopathy, often resulting in heart failure (HF) with preserved or reduced ejection fraction.
Robin Willixhofer +25 more
wiley +1 more source