Results 91 to 100 of about 3,714,409 (289)

Clinical Longitudinal Evaluation After Regimen Stop (CLEAR) of Dupilumab in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Long‐term management strategies for severe chronic rhinosinusitis with nasal polyps (CRSwNP) increasingly include biologic therapy targeting Type 2 inflammation. However, data on outcomes after complete discontinuation of dupilumab following sustained disease control are scarce.
Patrick Huber, Manuel Lasch, Veronika Volgger, Clemens Stihl, Philipp Teupe, Fabienne Oettgen, Sophia Gantner, Moritz Gröger   +7 more
wiley   +1 more source

Comprehensive Metabolomics in Mouse Mast Cell Model of Allergic Rhinitis for Profiling, Modulation, Semiquantitative Analysis, and Pathway Analysis

Biomolecules
Allergic rhinitis affects millions globally, causing significant discomfort and reducing the quality of life. This study investigates the metabolic alterations in murine mast cells (MC/9) under allergic rhinitis conditions induced by lipopolysaccharide ...
Akshay Suresh Patil, Yan Xu
doaj   +1 more source

The Employment of Leukotriene Antagonists in Cutaneous Diseases Belonging to Allergological Field

Mediators of Inflammation, 2010
Leukotrienes (LTs) are potent biological proinflammatory mediators. LTC4, LTD4, and LTE4 are more frequently involved in chronic inflammatory responses and exert their actions binding to a cysteinyl-LT 1 (CysLT1) receptor and a cysteinyl-LT 2 (CysLT2 ...
Eustachio Nettis, Maddalena D'Erasmo, Elisabetta Di Leo, Gianfranco Calogiuri, Vincenzo Montinaro, Antonio Ferrannini, Angelo Vacca   +6 more
doaj   +1 more source

Biologics Adoption in CRSwNP and the Associated Decline in Endoscopic Sinus Surgery: A Longitudinal Claims Database Study

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Biologic treatments were introduced for chronic rhinosinusitis with nasal polyps (CRSwNP) in 2019. Treatment algorithms for medically refractory CRSwNP remain open, with patients choosing among surgery, biologics, or both. Real‐world utilization of surgery and biologics remains incompletely characterized.
Stephanie Shintani Smith, Sam L. Kaefer, Harsh Duvvuru, Robert C. Kern, Brent A. Senior, Vijay R. Ramakrishnan   +5 more
wiley   +1 more source

Synthesis and Anti-Platelet, Anti-Inflammatory and Anti-Allergic Activities of Methoxyisoflavanquinone and Related Compounds

, 2009
In a continuation of our search for novel anti-platelet agents, isoflavone quinone and isoflavanquinone were selected as lead compounds and the synthesis of their methoxy derivatives was carried out, Among them , the 4'- and 7-methoxy derivatives were ...
鄧哲明, TENG, CHE-MING
core  

Irreversible Electroporation for Inferior Turbinate Reduction Ablation in Adults

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Inferior turbinate hypertrophy is a common cause of nasal airway obstruction. An optimal surgical approach should provide effective volume reduction while preserving mucosal integrity and minimizing postoperative morbidity. Objective To evaluate the safety and efficacy of irreversible electroporation (IRE) for non‐thermal ablation ...
Narin Nard Carmel Neiderman, Codrut Sarafoleanu, Ionut Tanase, Mihai Alexandru Pascu, Desiderio Passali, Ulugbek Saidakramovich Khasanov, Ulugbek Nuridinovich Vokhidov, Eugenijus Lesinskas, Marius Polianskis, Avraham Abergel   +9 more
wiley   +1 more source

Well Known and Unknown Asthma Phenotype: Allergic Asthma

European Medical Journal Allergy & Immunology, 2019
Allergic asthma is the most common phenotype of asthma and presents with various clinical subtypes and clusters, emphasising the importance of personalised treatments in its management.
Ayse Bilge Öztürk, Sadi Can Sönmez, Emre Göğebakan, Leyla Pur Özyiğit, Benan Çağlayan   +4 more
doaj  

Synthetic Particulate Subunit Vaccines Co‐Delivering Multiple Antigens Induce Protective Immunity Against Melioidosis

Advanced NanoBiomed Research, EarlyView.
Engineered endotoxin‐free Escherichia coli were used to assemble poly(3‐hydroxybutyrate) (PHB) biopolymer particles displaying multiple conserved Burkholderia pseudomallei antigens via PhaC‐mediated surface presentation. Following formulation with poly(I:C), the particulate vaccines induced antigen‐specific humoral and cellular immune responses ...
Md. Tanvir Kabir, Shuxiong Chen, Justine B. Bendo, Ashley Johnson, Aleksandra W. Debowski, Mitali Sarkar‐Tyson, Bernd H. A. Rehm   +6 more
wiley   +1 more source

Designing, docking and molecular dynamics simulation studies of novel cloperastine analogues as anti-allergic agents: homology modeling and active site prediction for the human histamine H1 receptor. [PDF]

RSC Adv, 2020
Daddam JR, Sreenivasulu B, Peddanna K, Umamahesh K.   +3 more
europepmc   +1 more source

Drug-Induced Anaphylaxis in Children

Biomedicines
Drug-induced anaphylaxis in children is less common than in adults and primarily involves beta-lactams and nonsteroidal anti-inflammatory drugs. Epidemiological studies show variable prevalence, influenced by age, gender, and atopic diseases.
Annamaria Bianchi, Rocco Valluzzi, Giuseppe Crisafulli, Paolo Bottau, Silvia Caimmi, Fabrizio Franceschini, Lucia Liotti, Francesca Mori, Sara Riscassi, Francesca Saretta, Sara Scavone, Carlo Caffarelli   +11 more
doaj   +1 more source