Results 101 to 110 of about 3,948,358 (329)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Review of Race Scholarship and the War on Terror [PDF]

open access: yes, 2018
The 9/11 terrorist attacks and heavy-handed state and popular response to them stimulated increased scholarship on American Muslims. In the social sciences, this work has focused mainly on Arabs and South Asians, and more recently on African Americans ...
Cainkar, Louise, Selod, Saher
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon   +12 more
wiley   +1 more source

Introduction: US Gun Culture and the Performance of Racial Sovereignty

open access: yesLateral, 2020
This introduction examines gun culture in the United States and argues that it is a product of the longstanding practices of settler colonialism, anti-Blackness, and misogyny that have shaped life in the United States.
Lindsay Livingston, Alex Trimble Young
doaj   +1 more source

Anti-Black Racism

open access: yes
Drawing on conversations with a queer interlocutor who moved to Austria to escape persecution in their country of origin, I reflect on the limits of legal protection in the host country when and if it is not accompanied by social change. I focus on the tension introduced by anti-black racism that comes in the way of queer solidarity.
openaire   +2 more sources

The State of Black Immigrants Part II: Black Immigrants in the Mass Criminalization System [PDF]

open access: yes, 2016
Black immigrants are one of the fastest growing demographics in the United States. Nonetheless, this group remains a novelty in the broader immigration discourse.
Juliana MorganTrostle, Kexin Zheng
core  

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic   +6 more
wiley   +1 more source

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