Results 31 to 40 of about 6,599,962 (291)

Anti-cancer drugs for cardioprotection [PDF]

Cell Cycle, 2016
Cardiovascular disease and cancer are the first and second common cause of death globally. An estimated 17.5 million people died from cardiovascular disease and 8.2 million died from cancer in 2012...
Nan, Wu, Yizhen, Xie, Burton B, Yang
openaire   +2 more sources

Childhood, adolescent and young adult cancer: cancer trends report

, 2023
This is the third Cancer Trends Report the National Cancer Registry Ireland (NCRI) has published on childhood cancers and the first to include cancers in adolescents and young adults (AYA) (up to 24 years of age).
National Cancer Registry Ireland (NCRI)
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Recent Advances In Developing Novel Anti-Cancer Drugs Targeting Tumor Hypoxic and Acidic Microenvironments.

, 2018
BACKGROUND:Solid tumors often contain hypoxic microenvironments due to abnormal vasculatures and outweighing demands of oxygen. Cancer cells rely on anaerobic respiration, leading to sequential acidic microenvironments.
Li, Weidong, Sun, Xueying
core   +1 more source

Anti-CA15.3 and anti-CA125 antibodies and ovarian cancer risk: Results from the EPIC cohort [PDF]

, 2018
BACKGROUND: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3 and CA125, and generate antibodies against them; but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined.
Antonia Trichopoulou, Chirlaque, Maria-Dolores, Merritt, Melissa A., Eleni Peppa, Johnson, Theron, Onland-Moret, N Charlotte, Giuseppe Matullo, Orfanos, Philippos, Travis, Ruth C., Amalia Mattiello, Maria-Jose Sánchez-Perez, Khaw, Kay-Tee, Cramer, Daniel W, Duell, Eric J, Ruth C. Travis, Heiner Boeing, Marie-Christine Boutron-Ruault, Palli, Domenico, Marc Gunter, Korgh, Vittorio, Maria-Dolores Chirlaque, Yamamoto, Hidemi S, Chirlaque, Maria Dolores, Gunter, Marc, Mattiello, Amalia, Gram, Inger T., Fortner, Renee T., Vittorio Krogh, Boutron-Ruault, Marie Christine, Mattiello, Amalie, Rudolf Kaaks, Kaaks, Rudolf, Vitonis, Allison F., Krogh, Vittorio, Vitonis, Allison F, Raina N. Fichorova, Rosario Tumino, Matullo, Giuseppe, Domenico Palli, Peppa, Eleni, Eva Ardanaz, Idahl, Annika, Sanchez-Perez, Maria Jose, Laure Dossus, Jenny Brändstedt, Dorronsoro, Miren, Severi, Gianluca, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Travis, Ruth C, Melissa A. Merritt, Inger T. Gram, Anne Tjønneland, Cramer, Daniel W., Onland-Moret, N. Charlotte, Gunter, Marc J, Theron Johnson, Kay-Tee Khaw, Eric J. Duell, Allison F. Vitonis, Weiderpass, Elisabete, Dagfinn Aune, Renée T. Fortner, Nodin, Björn, Trichopoulou, Antonia, Annika Idahl, Kathryn L. Terry, Miren Dorronsoro, Daniel W. Cramer, Gram, Inger T, Fichorova, Raina N., Tumino, Rosario, Marina Kvaskoff, Aune, Dagfinn, Merritt, Melissa A, Hansen, Louise, Hidemi Yamamoto, Terry, Kathryn L., Yamamoto, Hidemi, Duell, Eric J., Ardanaz, Eva, Brändstedt, Jenny, Kvaskoff, Marina, Fortner, Renée Turzanski, Quiros, J. Ramon, Quirós, J Ramón, N. Charlotte Onland-Moret, Björn Nodin, Philippos Orfanos, Fortner, Renée T, Idahl, Annika,, Khaw, Kay Tee, J. Ramón Quirós, Terry, Kathryn L, Louise Hansen, Elisabete Weiderpass, Dossus, Laure, Gianluca Severi, Fichorova, Raina N, Boeing, Heiner, Sànchez-Pérez, Maria-José, Severi, G., Fichorova, Raina N.,, Mattiello, Amalia,, Fortner, Renee T.,, Gunter, Marc,, Orfanos, Philippos,, Vitonis, Allison F.,, Dossus, Laure,, Lund University., Aune, D, Terry, Kathryn L.,, Boeing, H, Ardanaz, E, Merritt, Melissa A.,, Cramer, DW, Johnson, Theron,, Weiderpass, Elisabete,, Gram, Inger T.,, Nodin, Bjorn,, Travis, Ruth C.,, Vitonis, AF, Tjønneland, Anne,, Quiros, J. Ramon,, Khaw, Kay Tee,, Trichopoulou, Antonia,, Yamamoto, H, Braendstedt, J, Palli, Domenico,, Duell, Eric J.,, Hansen, Louise,, Kaaks, Rudolf,, Chirlaque, Maria Dolores,, Cramer, Daniel W.,, Brandstedt, Jenny,, Peppa, Eleni,, Onland-Moret, N. Charlotte,, Fichorova, RN, Boutron-Ruault, M-C, Boeing, Heiner,, Terry, KL, Aune, Dagfinn,, Matullo, Giuseppe,, Yamamoto, Hidemi,, Krogh, Vittorio,, Ardanaz, Eva,   +145 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Cancer trends: Breast, cervical and colorectal cancer 1994-2019: National trends for cancers with population-based screening programmes in Ireland

, 2022
The overall burden of cancer in Ireland is increasing, primarily due to population growth and ageing, with the annual number of cases of breast cancer, cervical cancer and colorectal cancer estimated to increase by 50%, 56% and 113% respectively by 2045 ...
National Cancer Registry Ireland (NCRI)
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Mitosis as an anti-cancer target [PDF]

Oncogene, 2011
Most of the current drugs used to treat cancer can be classified as anti-proliferative drugs. These drugs perturb the proliferative cycle of tumor cells at diverse stages of the cell cycle. Examples of such drugs are DNA-damaging agents and inhibitors of cyclin-dependent kinases that arrest cell cycle progression at different stages of interphase ...
A, Janssen, R H, Medema
openaire   +2 more sources