Results 101 to 110 of about 2,440,973 (235)

Anti-cyclic citrullinated peptide antibody titers decrease in rheumatoid arthritis patients treated with tocilizumab: A pilot study [PDF]

, 2019
Objectives: To analyze the effects of tocilizumab on peripheral B-cell subpopulation and its ability to produce anti-cyclic citrullinated peptide (CCP) antibody in patients with rheumatoid arthritis (RA).
Toshiyuki Bohgaki (222986), Yasuda, Shinsuke, Masaru Kato (1298340), Miho Suzuki (207444), Yoshihiro Matsumoto (31279), Atsushi Noguchi (2986758), Ryo Hisada (6494081), Oku, Kenji, Tatsuya Atsumi (186298), Kenji Oku (2986761), Atsumi, Tatsuya, Kato, Masaru, Hisada, Ryo, Matsumoto, Yoshihiro, Bohgaki, Toshiyuki, Shinsuke Yasuda (2986755), Noguchi, Atsushi, Suzuki, Miho   +17 more
core   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

A De Novo ATP1A3 p.Arg995His Variant in a Patient With an Adult‐Onset Primary Lateral Sclerosis‐Like Syndrome

Clinical Genetics, EarlyView.
A 43‐year‐old woman developed a progressive adult‐onset upper motor neuron syndrome fulfilling the clinical criteria for primary lateral sclerosis (PLS), with mild cerebellar involvement. Genetic testing identified a de novo ATP1A3 p.Arg995His variant affecting a highly conserved residue within the transmembrane M8 domain.
Pablo Hernandez‐Vitorique, Marta García de Burgos, Ana Campos Villegas, María José Gómez Heredia, Pilar Carbonell Corvillo   +4 more
wiley   +1 more source

A Case of Recurrent Gastric Cancer in Which Rheumatoid Arthritis and Sjögren's Syndrome Became Evident With Nivolumab. [PDF]

Clin Case Rep
ABSTRACT A 59‐year‐old man with recurrent gastric cancer began nivolumab as third‐line therapy and subsequently experienced joint pain and dry eyes. Symptoms worsened despite NSAIDs. He was diagnosed with rheumatoid arthritis and Sjögren's syndrome, associated with nivolumab, and was successfully treated with immunosuppressive and anti‐rheumatic ...
Takemoto H, Nishibeppu K, Kubota T, Inoue H, Takabatake K, Konishi H, Fujiwara H, Shiozaki A.   +7 more
europepmc   +2 more sources

Diagnostic value of Anti-CCP antibodies compared with Rheumatoid factor in Rheumatoid arthritis patients. [PDF]

, 2013
Citrullinated proteins have been discovered in the joints of patients with rheumatoid arthritis but not in other forms of joint disease. The citrullinated proteins in the joints correspond to the presence of the citrulline antibodies in the blood and ...
Hanaa N. Abdullah, Amina N.Al-Thuwani, Mohamed I. Nadi, Khudhair Al-Badri   +3 more
core   +2 more sources

Anti‐corruption as a Form of Governance? Balancing Growth and Risk in China's Financial Markets

Development and Change, EarlyView.
ABSTRACT This article examines how anti‐corruption campaigns function as unconventional instruments for regulating financial markets in emerging economies, where rapid market expansion often creates opportunities for dubious financial practices. Drawing on an original dataset of 393 investigations into alleged misconduct by personnel in China's ...
Yingyao Wang
wiley   +1 more source

Direct transition to a streamlined rheumatoid arthritis clinic improves outcomes after discharge from an early arthritis clinic environment

Internal Medicine Journal, EarlyView.
Abstract Background The treat‐to‐target (T2T) strategy for the management of rheumatoid arthritis (RA) achieves remission or low disease activity in many patients. However, RA T2T is challenging in real‐world clinical environments. In this two‐stage audit, we evaluated the impact of transferring patients from a T2T intensive early arthritis clinic (EAC)
Hyunjun Jonathan Kim, Mitsi Blazos, Kevin Yen Chia Su, Ranjeny Thomas, Helen Benham   +4 more
wiley   +1 more source

单独检测抗环瓜氨酸肽抗体以诊断类风湿关节炎

Zhongguo shiyan zhenduanxue, 2014
目的分别评价单独和联合检测抗环瓜氨酸肽抗体（anti-CCP）和类风湿因子（RF）等临床指标在诊断类风湿关节炎（RA）中的作用。方法速率散射比浊法检测RF;酶联免疫吸附试验（ELISA）检测anti-CCP;间接免疫荧光法检测抗角蛋白抗体（AKA）和抗核周因子抗体（APF）。结果 anti-CCP的敏感性与RF相比无显著性差异（P>0.05）,但特异性显著高于RF（P0.05）,特异性却显著下降（P0.05）,检测anti-CCP/RF/AKA/APF,特异性显著下降（P0.05）,但敏感性均显著下降 ...
葛艳玲, 宋慧, 赵育靖
doaj  

Treatment strategies for interstitial granulomatous dermatitis: Systematic review and expert opinion

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Systematic review of 108 studies with a total of 182 patients with interstitial granulomatous dermatitis (IGD). IGD was frequently associated with systemic conditions or drug exposure. Management includes careful medication review and prompt withdrawal of potential triggers. Corticosteroids (systemic and topical) were commonly effective, while biologic
Francesco Bellinato, Sara Salvagno, Chiara Colato, Paolo Gisondi, Giampiero Girolomoni   +4 more
wiley   +1 more source

Educational Homogamy and Wealth: Assortative Mating, Spouses' Division of Paid Labor, and Net Worth in China

Journal of Marriage and Family, EarlyView.
ABSTRACT Objective This study examines how educational assortative mating—particularly educational homogamy—shapes household net worth in urban China. Background Despite private wealth emerging as a critical indicator of financial security and social status in post‐reform China, the family‐level processes that shape wealth accumulation remain ...
Yu Wang, Lisa A. Keister
wiley   +1 more source