Results 141 to 150 of about 7,906 (281)

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

Beyond eosinophils: A proteomic dissection of remodeling and inflammation in suspected eosinophilic esophagitis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Eosinophilic esophagitis (EoE) is characterized by eosinophilic inflammation and epithelial remodeling. However, current biomarkers focus predominantly on eosinophilia, overlooking basal cell hyperplasia (BCH), a histologic feature that may persist despite treatment.
Adi Eindor‐Abarbanel, Nimrod Moss‐ Ophir, Netanel Agajany, Daniel L. Cohen, Vered Richter, Haim Shirin, Efrat Broide, Tzippora Shalem   +7 more
wiley   +1 more source

Nasty shock after an anti‐emetic [PDF]

Nephrology Dialysis Transplantation, 2001
Maxwell, P, Buckley, C, Gleadle, J, Mason, P   +3 more
openaire   +2 more sources

Risk factors for early postoperative complications after minimally invasive surgery in pediatric ulcerative colitis

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective To report a single‐center experience with a multidisciplinary minimally invasive surgical approach for pediatric ulcerative colitis (UC) and identify risk factors for early postoperative complications (EPC). Methods A retrospective analysis was conducted on UC patients followed at the Gastroenterology Unit of Meyer Children's ...
Martina Di Benedetto, Luca Scarallo, Sara Renzo, Sara Naldini, Monica Paci, Jacopo Barp, Federico Perna, Emilio Paolo Emma, Riccardo Coletta, Stefano Scaringi, Paolo Lionetti   +10 more
wiley   +1 more source

Risk factors, pre-presentation management and clinical state of children with diarrhoea presenting in a community cottage hospital

Nigerian Journal of Paediatrics
Diarrhoael disease ranks second as the cause of under -five mortality worldwide and is particularly important in the developing world. Risk factors include water source, poor human and domestic waste disposal, poor hand washing and breastfeeding ...
Ekanem EE, Fajola AO, Umejiego CN, Ikeagwu GO, Anidima TE   +4 more
doaj  

Esophageal stenosis secondary to severe loxoscelism: A case report

JPGN Reports, EarlyView.
ABSTRACT Loxoscelism is a public health issue in tropical countries, particularly in Brazil. It can affect children of all ages and may lead to severe and irreversible injuries. We report the case of an infant who suffered a severe loxoscelism accident in the cervical region, progressing to esophageal stricture requiring multiple dilations. Fortunately,
Lucas Rocha Alvarenga, Mariana Di Paula Rodrigues, Marise Helena Cardoso Tofoli, Patrícia dos Santos Oliveira   +3 more
wiley   +1 more source

Gastrointestinal strictures in a pediatric patient with Satoyoshi syndrome

JPGN Reports, EarlyView.
Abstract We present a novel case of gastrointestinal strictures in a young girl with Satoyoshi syndrome (SS), highlighting multi‐system features of alopecia universalis, painful muscle cramps with dystonia, aberrant growth velocity, and skeletal abnormalities.
Katherine (Tusia) Pohoreski, Gary Galante, Kiera Pajunen, Marie‐Anne Brundler, Samarjeet Bhandal, Iwona Wrobel   +5 more
wiley   +1 more source

PERCC1‐associated enteropathy: Diagnostic challenges and enteral autonomy achieved with teduglutide

JPGN Reports, EarlyView.
Abstract Congenital diarrheas and enteropathies (CODE) are rare inherited disorders characterized by early‐onset intractable diarrhea. Though progress has been made in elucidating the genetic basis of CODE, much remains to be discovered. Another challenge is the lack of curative therapies—treatment is primarily supportive including enteral and ...
Angela Tran, Vivien Nguyen, Phuong Huynh
wiley   +1 more source

Phase IIb Trial for the Palliative Treatment of Patients With Primary Hepatic Malignancy Unable to Receive Curative Treatment: Efficacy of Colchicine

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This trial was to evaluate the efficacy and the safety of colchicine for the palliative treatment of patients with primary hepatic malignancy unable to receive curative treatment. Forty hepatocellular carcinoma (HCC) patients and two intrahepatic cholangiocarcinoma (ICC) patients signed the informed consents.
Zu‐Yau Lin, Ming‐Lun Yeh, Po‐Cheng Liang, Shinn‐Cherng Chen, Chung‐Feng Huang, Jee‐Fu Huang, Chia‐Yen Dai, Ming‐Lung Yu, Wan‐Long Chuang   +8 more
wiley   +1 more source

Identification of Clinical Factors Associated With the Immunogenicity of Homologous ChAdOx1‐nCoV‐19 Vaccine in Hemodialysis Patients

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hemodialysis (HD) patients are at higher risk of severe COVID‐19 and may exhibit suboptimal vaccine responses. This study evaluates the factors influencing vaccine‐induced immunity in HD patients following the second dose of the Vaxzevria. A total of 276 HD patients and 126 controls were included. Antibody responses were assessed using binding
Chia‐Wei Chang, Ping‐Hsun Wu, Li‐Yun Chang, Yu‐Ying Huang, Teng‐Hui Huang, Su‐Chu Lee, Yi‐wen Chiu, Shang‐Jyh Hwang, Tsun‐Yung Kuo, Mei‐Chuan Kuo   +9 more
wiley   +1 more source