Results 31 to 40 of about 232,040 (295)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A anti-globalização e o livre-comércio
Meridiano 47, 2017 Um dos temas mais recentes no que tange aos movimentos anti-globalização é o livre-comércio. Nesse sentido o presente artigo busca analisar essa questão e suas conseqüências.
Paulo Roberto de Almeida
doaj
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Contradições, insuficiências e impasses do movimento anti-globalizador
Meridiano 47, 2011 O presente artigo analisa criticamente os impasses e contradições da teoria anti-globalização.
Paulo Roberto Almeida
doaj
Traveling the Distances of Karen Tei Yamashita\u27s Fiction: A Review Essay on Yamashita Scholarship and Transnational Studies [PDF]
, 2010 This essay provides an analysis of scholarly works on the fiction of Karen Tei Yamashita, contextualizing them within major shifts taking place in a number academic disciplines and fields that are addressing ...
Thoma, Pamela
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
No meio do caminho tinha um mercado
Meridiano 47, 2017 O presente artigo busca analisar criticamente os problemas decorrentes da ideologia proposta pelos denominados anti-globalizadores.
Paulo Roberto Almeida
doaj
Framing children's citizenship: exploring the space of children's claims for social justice using Nancy Fraser's conception of representation [PDF]
, 2012 This paper seeks to contribute to a dynamic understanding of the space of children‟s citizenship by exploring perspectives generated by children age 5-13 in two countries in the light of Nancy Fraser‟s (2008) theory of representation.
Larkins, Cath
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Concentração da renda e desigualdades
Meridiano 47, 2017 O presente artigo tem como objetivo delinear as novas questões e constrangimentos existentes no século XXI sob o prisma dos movimentos anti-globalização.
Paulo Roberto Almeida
doaj