Results 1 to 10 of about 5,098 (134)

A randomized trial of viral vector and adjuvanted protein HBV therapeutic vaccine in people with chronic hepatitis B on nucleos(t)ide analogs [PDF]

Hepatology Communications
Background:. This study assessed the safety, efficacy, and immunogenicity of a therapeutic immunization strategy aimed at reaching a functional cure for chronic hepatitis B (CHB), relying on a heterologous prime-boost with viral vectors ChAd155-hIi-HBV ...
Wen-Juei Jeng, Chi-Jen Chu, Apinya Leerapun, Anchalee Avihingsanon, Stefan Zeuzem, Stefan Bourgeois, Man-Fung Yuen, Manuel Romero-Gomez, Sheng-Shun Yang, Cristina Cravcenco, Bruno Salaun, Meng Shi, Ventzislav Vassilev, Joon Hyung Kim, Kristien Swinnen, and the TH HBV VV-001 Study Group   +15 more
doaj   +2 more sources

Occult HBV among anti-HBc–reactive blood donors in Colombia: low HBsAg prevalence, genotype F3, and small-S variation relevant to HBsAg detectability [PDF]

Scientific Reports
Purpose Occult hepatitis B infection (OBI) can sustain residual transfusion risk because HBV DNA may persist at very low levels while HBsAg remains undetectable by routine serology. We assessed OBI among anti-HBc–reactive, HBsAg-negative (anti-HBc+/HBsAg−
Henry Bautista-Amorocho, Jorge Alexander Silva-Sayago, Yeny Zulay Castellanos-Domínguez   +2 more
doaj   +2 more sources

Combined HBsAg and anti-HBc testing is required to estimate hepatitis B virus seroprevalence in a low-endemic country: findings from a nationwide population-based serosurvey, Belgium, 2020 [PDF]

Eurosurveillance
BACKGROUND The World Health Organization aims to eliminate hepatitis B virus (HBV) by 2030 through reducing incidence and mortality. Accurate prevalence estimates are crucial to guide policies and monitor progress towards HBV elimination.
Thomas Vanwolleghem
doaj   +2 more sources

Serology change-based clinical interpretation of indeterminate serostatus post-hepatitis B virus infection in people living with HIV. [PDF]

PLoS ONE
After hepatitis B virus (HBV) infection in people living with HIV (PLWH), various forms of indeterminate serostatuses, including "isolated anti-HBc (IAHBc)", are observed, but the current interpretation for their HBV immunity seems to be optimistic. This
Ei Kinai, Mio Ishikura, Ryui Miyashita, Tomoko Yamaguchi, Yushi Chikasawa, Akito Ichiki, Ryoko Sekiya, Masato Bingo, Takashi Muramatsu, Mihoko Yotsumoto, Takeshi Hagiwara, Kagehiro Amano   +11 more
doaj   +2 more sources

Serological and Molecular Epidemiology of Hepatitis B, C, and D Viruses in Northwest Russia: A Population-Based Cross-Sectional Study [PDF]

Viruses
The hepatitis B (HBV), C (HCV), and D (HDV) viruses remain a major public health burden. Occult HBV infection (OBI) represents a hidden reservoir with clinical and epidemiological significance, yet its prevalence in Northwest Russia is unknown.
Anna Y. Popova, Yulia V. Ostankova, Alesia Y. Olkhovskaya, Olga A. Petrova, Alexandr N. Shchemelev, Elena N. Serikova, Svetlana A. Egorova, Diana E. Reingardt, Irina V. Drozd, Ojuna B. Zhimbaeva, Ekaterina M. Danilova, Angelica M. Milichkina, Elena B. Ezhlova, Albina A. Melnikova, Natalia S. Bashketova, Lidiya V. Buts, Edward S. Ramsay, Areg A. Totolian   +17 more
doaj   +2 more sources

Implications of occult hepatitis B infection for blood donor management: a five-year evaluation from Western Saudi Arabia [PDF]

BMC Infectious Diseases
Background Occult hepatitis B infection (OBI), defined by detectable HBV DNA in the absence of hepatitis B surface antigen (HBsAg), remains a diagnostic challenge and a potential source of transfusion-transmitted infection.
Wajnat A. Tounsi, Somaya Noorsaeed, Amany I. Almars, Mona M. Almramhi, Ahmed M. Basri, Ammar A. Basabrain, Ahmed Rokan, Taghreed S. Almansouri, Sara H. Mokhtar, Nora Y. Hakami   +9 more
doaj   +2 more sources

Cost-effectiveness and long-term outcomes of liver transplantation using hepatitis B core antibody-positive grafts with hepatitis B immunoglobulin prophylaxis in Korea [PDF]

Clinical and Molecular Hepatology, 2021
Background/Aims Hepatitis B core antibody (anti-HBc)-positive donors are used as an extended donor pool, and current guidelines recommend the usage of nucleos(t)ide analogues (NAs) as prophylaxis for preventing de novo hepatitis B virus infection (DNH ...
Kyeong Deok Kim, Ji Eun Lee, Jong Man Kim, Okjoo Lee, Na Young Hwang, Jinsoo Rhu, Gyu-Seong Choi, Kyunga Kim, Jae-Won Joh   +8 more
doaj   +1 more source

Seroprevalence of Hepatitis B Virus Infection among the Tribal Population of Attapady, Kerala, India [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: Hepatitis B Virus (HBV) infection remains a significant global health concern that may cause acute or chronic hepatitis. Chronically infected patients are at risk for cirrhosis and hepatocellular carcinoma.
Irene Jose Manjiyil, Kavitha Paul Konikkara   +1 more
doaj   +1 more source

Serological and molecular characterization of hepatitis B virus infection in chronic kidney disease patients from Rio de Janeiro, Brazil

Brazilian Journal of Infectious Diseases, 2022
Chronic kidney disease (CKD) patients undergoing hemodialysis (HD) are more vulnerable to blood-borne viral infections due to frequent invasive procedures.
Livia Melo Villar, Ketlyn Araujo Fraga, Ana Carolina da Fonseca Mendonça, Juliana Custódio Miguel, Elisangela Ferreira da Silva, Jakeline Ribeiro Barbosa, Paulo Sérgio Fonseca de Sousa, Lia Laura Lewis-Ximenez, Francisco Campello do Amaral Mello   +8 more
doaj   +1 more source

Quantitative of serum hepatitis B core antibody is a potential predictor of recurrence after interferon-induced hepatitis B surface antigen clearance

Journal of Microbiology, Immunology and Infection, 2021
Background: Recurrence is common for patients with chronic hepatitis B (CHB) who achieved hepatitis B virus (HBV) surface antigen (HBsAg) clearance after antiviral treatment.
Yali Wu, Xiaoxiao Wang, Xiao Lin, Chengli Shen, Xinyue Chen   +4 more
doaj   +1 more source