Results 21 to 30 of about 365,213 (214)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. [PDF]

, 2018
Neuronal cell morphogenesis depends on proper regulation of microtubule-based transport, but the underlying mechanisms are not well understood.
Ma, Le, Tymanskyj, Stephen R., Verhey, Kristen J., Yang, Benjamin   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

City Rights in an Era of Preemption: A State-by-State Analysis [PDF]

, 2017
In a new report, NLC finds that states limit city power through preemption in a number of policy areas, ranging from labor protections to taxing authority.Preemption is the use of state law to nullify a municipal ordinance or authority.
Angelina Panettieri, Brooks Rainwater, Christiana McFarland, Nicole Dupuis, Trevor Langan   +4 more
core  

Large-scale solar wind flow around Saturn's nonaxisymmetric magnetosphere [PDF]

, 2017
The interaction between the solar wind and a magnetosphere is fundamental to the dynamics of a planetary system. Here, we address fundamental questions on the large-scale magnetosheath flow around Saturn using a 3D magnetohydrodynamic (MHD) simulation ...
Achilleos, N., Gurnett, D. A., Jia, X., Kurth, W. S., Sergis, N., Sulaiman, A. H.   +5 more
core   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Housing supply and planning delay in the South of England [PDF]

, 2008
There is growing international interest in the impact of regulatory controls on the supply of housing The UK has a particularly restrictive planning regime and a detailed and uncertain process of development control linked to it.
Allmendinger, Philip, Ball, Michael, Hughes, Cathy   +2 more
core  

Statistical Issues in Astrophysical Searches for Particle Dark Matter

, 2014
In this review statistical issues appearing in astrophysical searches for particle dark matter, i.e. indirect detection (dark matter annihilating into standard model particles) or direct detection (dark matter particles scattering in deep underground ...
Conrad, Jan
core   +1 more source

Manufacturing Dendritic Cells for Immunotherapy: Monocyte Enrichment [PDF]

, 2020
Dendritic cells play a key role in activation of the immune system as potent antigen-presenting cells. This pivotal position, along with the ability to generate dendritic cells from monocytes and ready uptake of antigen, makes them an intriguing vehicle ...
Cox, Cheryl, Hopewell, Emily L.
core   +1 more source