Prospective assessment of pre-existing and de novo anti-HLA IgE in kidney, liver, lung and heart transplantation [PDF]
Frontiers in Immunology, 2023 IntroductionAntibody mediated rejection (ABMR) is a major factor limiting outcome after organ transplantation. Anti-HLA donor-specific antibodies (DSA) of the IgG isotype are mainly responsible for ABMR.
Jasmin Mucha +16 more
doaj +2 more sources
Anti-HLA antibodies bound to monocytes altered antibody-mediated platelet phagocytosis and led to mild thrombocytopenia [PDF]
Frontiers in ImmunologyBackgroundIn fetal and neonatal alloimmune thrombocytopenia (FNAIT), maternal antibodies react with alloantigen expressed on fetal platelets, leading to their clearance via antibody-dependent phagocytosis.
Xiuzhang Xu +14 more
doaj +2 more sources
Immunogenicity of Anti-HLA Antibodies in Pancreas and Islet Transplantation [PDF]
Cell Transplantation, 2016 The aim of the current study was to characterize the anti-HLA antibodies before and after pancreatic islet or pancreas transplantation. We assessed the risk of anti-donor-specific antibody (DSA) sensitization in a single-center, retrospective clinical study at Geneva University Hospital.
Benjamin Chaigne +2 more
exaly +8 more sources
Existence and significance of anti-HLA-C autoantibodies to primary and persistent platelet transfusion refractoriness in patients with hematologic disorders: a retrospective study from a single centre [PDF]
Annals of MedicineObjectives Platelet transfusion refractoriness (PTR) is a frustrating clinical problem, and primary and persistent (P/P) PTR who experienced persistent PTR since the first transfusion was failed to be well recognized.
Xunhua Li +17 more
doaj +2 more sources
Complement-activating donor-specific anti-HLA antibodies in solid organ transplantation: systematic review, meta-analysis, and critical appraisal [PDF]
Frontiers in Immunology, 2023 IntroductionSeveral studies have investigated the impact of circulating complement-activating anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) on organ transplant outcomes.
Solaf Al-Awadhi +12 more
doaj +2 more sources
Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients [PDF]
Frontiers in ImmunologyOrgan transplantation is a lifesaving procedure, with 50,000 transplants happening every year in the United States. However, many patients harbor antibodies and B cells directed against allogeneic human leukocyte antigen (HLA) molecules, notably HLA-A2 ...
Jaime Valentín-Quiroga +6 more
doaj +2 more sources
The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT [PDF]
Immunity & AgeingBackground With the development of Hematopoietic Stem Cell Transplantation (HSCT) technology, increasing numbers of elderly patients were undergoing allogeneic HSCT and elderly patients with hematologic malignancies could benefit most from it.
Qinqin Pan +11 more
doaj +2 more sources
Evaluation of the level of alloantibodies and selected cytokines in kidney recipients
Journal of Pre-Clinical and Clinical Research, 2022 Introduction and objective Anti-HLA antibodies, especially anti-DSA, are believed to be potentially involved in acute and chronic rejection. New techniques, e.g. flow fluorimetry, can be an excellent supplement to the lymphocytotoxic tests currently used
Iwona Wojciechowska-Koszko +5 more
doaj +1 more source
Platelets, 2023 Immune-mediated platelet refractoriness (PR) remains a significant problem in the setting of platelet transfusion and is predominantly caused by the presence of alloantibodies directed against class I human leukocyte antigens (HLA). Opsonization of donor
Thijs L. J. van Osch +11 more
doaj +1 more source
EBioMedicine, 2023 Summary: Background: In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity.
Valérie Leclair +71 more
doaj +1 more source