Results 221 to 230 of about 2,385,197 (304)

LC‐OCT of Dermatitis Herpetiformis

JEADV Clinical Practice, EarlyView.
Daniele Omar Traini, Gerardo Palmisano
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Donor-specific anti-HLA antibodies (DSAs) in patients undergoing allogeneic hematopoietic stem cell transplantation from mismatched donors on behalf of GITMO and AIBT. [PDF]

Blood Transfus
La Rocca U, Ricci R, Piciocchi A, Barberi W, Oldani E, Dominietto A, Cerretti R, Picardi A, Bonifazi F, Saccardi R, Faraci M, Grillo G, Farina L, Bruno B, Grassi A, Proia A, Tagliaferri E, De Simone G, Malagola M, Cerno M, Cesaro S, Bernasconi P, Prezioso L, Carluccio P, Mordini N, Pelosini M, Olivieri A, Chiusolo P, Santarone S, Cimminiello M, Crocchiolo R, Papola F, Rombolà G, Sacchi N, Miotti V, Mele L, Mazzi B, Ciceri F, Martino M, Iori AP.   +39 more
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Enhanced Recovery After Surgery in Simultaneous Pancreas–Kidney Transplantation: A Retrospective Cohort Analysis of Perioperative Outcomes

Organ Medicine, EarlyView.
ABSTRACT Background While simultaneous pancreas–kidney transplantation (SPK) is an established therapeutic intervention for patients with end‐stage renal disease and diabetes, it has been associated with prolonged recovery periods and high complication rates.
Rongxin Chen, Luhao Liu, Jialin Wu, Zhuangqiang Fang, Guanghui Li, Zheng Chen   +5 more
wiley   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Anti-HLA Class II Antibodies Are the Most Resistant to Desensitization in Crossmatch-positive Living-donor Kidney Transplantations: A Patient Series. [PDF]

Transplant Direct
de Weerd AE, Roelen DL, Betjes MGH, Clahsen-van Groningen MC, Haasnoot GW, Kho MML, Reinders MEJ, Roodnat JI, Severs D, Karahan GE, van de Wetering J.   +10 more
europepmc   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

<i>De Novo</i> donor-specific anti-HLA antibody risk stratification in kidney transplantation using a combination of B cell and T cell molecular mismatch assessment. [PDF]

Front Immunol
Chou-Wu E, Niemann M, Youngs D, Gimferrer I.   +3 more
europepmc   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source