Results 181 to 190 of about 2,071,364 (242)

The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors. [PDF]

J Clin Invest, 2020
Balbino B, Herviou P, Godon O, Stackowicz J, Goff OR, Iannascoli B, Sterlin D, Brûlé S, Millot GA, Harris FM, Voronina VA, Nadeau KC, Macdonald LE, Murphy AJ, Bruhns P, Reber LL.   +15 more
europepmc   +1 more source

Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy

Allergy, EarlyView.
Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin   +16 more
wiley   +1 more source

Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study. [PDF]

Am J Respir Crit Care Med
Djukanović R, Brinkman P, Kolmert J, Gomez C, Schofield J, Brandsma J, Shapanis A, Skipp PJS, Postle A, Wheelock C, Dahlen SE, Sterk PJ, Brown T, Jackson DJ, Mansur A, Pavord I, Patel M, Brightling C, Siddiqui S, Bradding P, Sabroe I, Saralaya D, Chishimba L, Porter J, Robinson D, Fowler S, Howarth PH, Little L, Oliver T, Hill K, Stanton L, Allen A, Ellis D, Griffiths G, Harrison T, Akenroye A, Lasky-Su J, Heaney L, Chaudhuri R, Kurukulaaratchy R, SoMOSA study team and the U-BIOPRED study team.   +40 more
europepmc   +1 more source

The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. [PDF]

Nat Commun, 2020
Gasser P, Tarchevskaya SS, Guntern P, Brigger D, Ruppli R, Zbären N, Kleinboelting S, Heusser C, Jardetzky TS, Eggel A.   +9 more
europepmc   +1 more source

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source

Distinct maturation, glucose metabolism, and inflammatory function of human monocytes-derived IDECs mediated by anti-IgE and Pam3CSK4 alone or in combination. [PDF]

Front Immunol
Gao C, Zhao Y, Ge L, Liu W, Zhang M, Ni B, Song Z.   +6 more
europepmc   +1 more source

Comparison of the therapeutic effects of medication therapy, specific immunotherapy and anti-IgE (Omalizumab) in patients with hay fever. [PDF]

Front Immunol
Tang R, Lyu X, Hou Y, Yang Y, Fu G, Zhu L, Xue L, Li H, Wang R.   +8 more
europepmc   +1 more source

Treatment with the anti-IgE monoclonal antibody omalizumab in women with asthma undergoing fertility treatment: a proof-of-concept study-The PRO-ART study protocol. [PDF]

BMJ Open, 2020
Tidemandsen C, Juul Gade E, Ulrik CS, Nielsen HS, Oxlund-Mariegaard BS, Kristiansen K, Freiesleben NC, Nøhr B, Udengaard H, Backer V.   +9 more
europepmc   +1 more source

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial

Allergy, EarlyView.
Both Full and Limited FESS result in clinically meaningful relief of disease‐specific HRQoL and nasal breathing, effectively improving nasal symptoms and sleep disturbance in CRSwNP patients. Clinically meaningful difference in decrease of SNOT‐22 scores between the groups was not found at 12‐ and 24–month follow‐up.
P. Virkkula, S. Hammarén‐Malmi, A. Laulajainen‐Hongisto, M. Lilja, J. Wikstén, L. Hafrén, P. Kauppi, S. Reitsma, K. Pajala, J. Sahlman, S. Toppila‐Salmi   +10 more
wiley   +1 more source

Eosinophilic Meningoencephalitis Occurred during Oral Corticosteroid Tapering and after Switching from Anti-IL-5 to Anti-IgE Treatment. [PDF]

Intern Med
Nishii Y, Kinoshita T, Sasaki J, Tsuneyoshi S, Irie K, Tateishi T, Tominaga M, Taniwaki T, Hoshino T, Kawayama T.   +9 more
europepmc   +1 more source