Results 181 to 190 of about 55,637 (232)

Usefulness of a hub and spoke TDM-guided expert clinical pharmacological advice program of dalbavancin for optimizing very long-term curative or suppressive treatment of chronic staphylococcal infections. [PDF]

Antimicrob Agents Chemother
Cojutti PG, Gatti M, Tedeschi S, Zamparini E, Meschiari M, Danzi M, Menegotto G, Cotrufo M, Soavi L, Chiari E, Ripa M, Mazzitelli M, Crapis M, Cattelan A, Parruti G, Russo A, Zammarchi L, Tascini C, Viale P, Pea F.   +19 more
europepmc   +1 more source

A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin, Ye Wu, Xiao‐Hui Liang, Min Tang, Xin Sun, Sheng‐Xin Lu, Jin‐Mei Jin, Xin Guo, Bei Wang, Hong‐Zhuan Chen, Wei‐Dong Zhang, Xin Luan   +11 more
wiley   +1 more source

Fractional inhibitory concentration of bio-actives from agricultural waste disassembles biofilms and quenches virulence of nosocomial pathogens. [PDF]

J Med Microbiol
Krishnan S, Venkatachalam P, Shanmugam SR, Paramasivam N.   +3 more
europepmc   +1 more source

Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model

Advanced Science, EarlyView.
Nano‐pulling is a magnetic nanoparticle‐based technology for guiding and promoting the axon growth of induced pluripotent stem cell‐derived dopaminergic neurospheres in vitro or neural progenitors transplanted in the brain tissue. Fine control of axon guidance is essential for reconstructing neural networks and restoring functional connectivity in the ...
Sara De Vincentiis, Elena Capitanini, Karen Kira, Claudia Dell'Amico, Jun Takahashi, Marco Onorati, Fabian Raudzus, Vittoria Raffa   +7 more
wiley   +1 more source

Current State and Advances in Antimicrobial Strategies for Burn Wound Dressings: From Metal-Based Antimicrobials and Natural Bioactive Agents to Future Perspectives. [PDF]

Int J Mol Sci
Osmokrovic A, Stojkovska J, Krunic T, Petrovic P, Lazic V, Zvicer J.   +5 more
europepmc   +1 more source

An Intelligent and Conductive Hydrogel with Multiresponsive and ROS Scavenging Properties for Infection Prevention and Anti‐Inflammatory Treatment Assisted by Electrical Stimulation for Diabetic Wound

Advanced Science, EarlyView.
This study introduces a novel therapeutic approach that employs a conductive hydrogel (HEPP) responsive to near‐infrared light, pH levels, and reactive oxygen species. Its goal is to enhance the healing environment affected by elevated glucose levels, insufficient oxygen, and bacterial infections in diabetes‐related wounds.
Tao Zhang, Zongwu Meng, Haoyu Yu, Ping Ding, Tianhan Kai   +4 more
wiley   +1 more source

A case report of implanted bone displacement after abscess formation. [PDF]

Medicine (Baltimore)
Chen XQ, Ma SP, Li YH, Xu SH.
europepmc   +1 more source

Ultrasound‐Triggered Nanocomposite “Lever” Hydrogels with a Full Repair System Accelerates Diabetic Foot Ulcer Repair

Advanced Science, EarlyView.
Ultrasound (US)‐treated nanocomposite ‘lever’ hydrogels reprogrammed wound reactive oxygen species (ROS) levels and promoted wound healing in infected diabetic foot ulcers. Abstract Diabetic foot ulcers (DFUs) are a complex mixture of neuropathy, peripheral arterial disease, and infection, where excessive reactive oxygen species (ROS) exacerbates ...
Yuting Shen, Shaoyue Li, Xiaodong Hou, Jifeng Yu, Yuli Zhu, Chongke Zhao, Zhiyuan Niu, Xin Guan, Bing Xiong, Sirui Wang, Yifei Yang, Xiao Li, Liping Sun, Shengbo Wu, Bin Huang, Huixiong Xu, Haohao Yin   +16 more
wiley   +1 more source

Plasma cell-free DNA Droplet Digital PCR provides rapid and efficient infectious microbiology diagnosis for febrile haematological patients. [PDF]

Front Cell Infect Microbiol
Li Y, Xiao J, Xia L, Sun X, Li J, Bai H.
europepmc   +1 more source

Neutrophil Macrophage Crosstalk via Extracellular Vesicles Drives Reverse Migration in a Fully Human Model of Wound Healing

Advanced Science, EarlyView.
A novel microphysiological system that can mimic sterile or non‐sterile injury demonstrates that macrophage‐derived extracellular vesicles modulate neutrophil migratory responses to these different wound states. The model showed that resolution of inflammation through neutrophil reverse migration is driven by IL‐8 derived from extracellular vesicles ...
Kehinde Adebayo Babatunde, Oluwadamilola Fatimat Babatunde, Adeel Ahmed, Wilmara Salgado‐Pabon, David J Beebe, Sheena C. Kerr   +5 more
wiley   +1 more source