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Pharmacokinetics of Non‐Steroidal Anti‐Inflammatory Agents

Australian and New Zealand Journal of Medicine, 1978
Summary: Pharmacokinetics of non‐steroidal anti‐inflammatory agents. G. D. Champion and G. G. Graham, Aust. N.Z. J. Med., 1978, 8, Suppl. 1, pp 94–100. The non‐steroidal anti‐inflammatory drugs (NSAID) are well absorbed from the gastrointestinal tract. The only known exception is aspirin.
G D, Champion, G G, Graham
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Pain control: Non-steroidal anti-inflammatory agents

Seminars in Fetal and Neonatal Medicine, 2006
The non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (paracetamol) are the most common analgesic drugs used in neonates and infants despite limited pharmacodynamic data. Both drugs act through inhibition of cyclooxygenase enzymes. Neonatal acetaminophen clearance is reduced in premature neonates (0.7 L h(-1) x 70 kg(-1)) and increases ...
Evelyne, Jacqz-Aigrain   +1 more
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The regulatory control of non-steroidal anti-inflammatory agents

European Journal of Clinical Pharmacology, 1981
The number of marketed non-steroidal anti-inflammatory agents varies widely from one European country to another, partly as a consequence of differing regulatory policies. During a four-year period, nine of 18 applications to market such drugs in the Netherlands failed; the remaining nine compounds were all licenced; in all, 22 single drug entities of ...
M N, Dukes, I, Lunde
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Non Steroidal Anti-Inflammatory and Anti-Allergy Agents

Current Medicinal Chemistry, 2002
Non steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used for inflammation therapy. The major drawback in using the NSAIDs is in their tendency to cause gastrointestinal toxicity. Since the roles of arachidonic acid (A.A) metabolites, as leukotrienes (Lts), prostaglandins (PGs) and thromboxanes (TXA(2)) as mediators of the ...
C A, Kontogiorgis   +1 more
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