Results 241 to 250 of about 96,642 (272)
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The regulatory control of non-steroidal anti-inflammatory agents
European Journal of Clinical Pharmacology, 1981The number of marketed non-steroidal anti-inflammatory agents varies widely from one European country to another, partly as a consequence of differing regulatory policies. During a four-year period, nine of 18 applications to market such drugs in the Netherlands failed; the remaining nine compounds were all licenced; in all, 22 single drug entities of ...
I. Lunde, M. N. G. Dukes
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Non Steroidal Anti-Inflammatory and Anti-Allergy Agents
Current Medicinal Chemistry, 2002Non steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used for inflammation therapy. The major drawback in using the NSAIDs is in their tendency to cause gastrointestinal toxicity. Since the roles of arachidonic acid (A.A) metabolites, as leukotrienes (Lts), prostaglandins (PGs) and thromboxanes (TXA(2)) as mediators of the ...
Christos Kontogiorgis +1 more
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Comparative toxicity of non-steroidal anti-inflammatory agents
Pharmacology & Therapeutics, 1994Comparative toxicity of non-steroidal anti-inflammatory drugs was assessed using the Stanford Toxicity Index consisting of weighted symptoms, laboratory abnormalities and hospitalizations in 2976 consecutively enrolled rheumatoid arthritis patients from eight data bank centers with 27,936 patient-years of observation.
Dena R. Ramey +3 more
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Pain control: Non-steroidal anti-inflammatory agents
Seminars in Fetal and Neonatal Medicine, 2006The non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (paracetamol) are the most common analgesic drugs used in neonates and infants despite limited pharmacodynamic data. Both drugs act through inhibition of cyclooxygenase enzymes. Neonatal acetaminophen clearance is reduced in premature neonates (0.7 L h(-1) x 70 kg(-1)) and increases ...
Brian J. Anderson, Evelyne Jacqz-Aigrain
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Non-steroidal Anti-inflammatory Agents and the Skin
1989The development of topical non-steroidal anti-inflammatory drugs (NSAIDs), devoid of the unwanted effects of corticosteroids but with equal or even greater potency, has been an unattained ideal for many years. Considerable impetus was given to the search by the discovery by Vane (1971) that aspirin and other NSAIDs owed their effectiveness, at least in
M. W. Greaves, S. Shuster
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Antimicrobial Activity of Benzydamine, a Non-Steroid Anti-Inflammatory Agent
Journal of Chemotherapy, 1992The antimicrobial activity of benzydamine (BD), a non-steroid anti-inflammatory agent, was studied using different techniques against 38 strains belonging to 12 microbial species comprising bacteria, yeasts and a fungus. The minimum inhibitory concentrations, minimum lethal concentrations, per cent survivors after 30-minute exposure to BD (0.1 ...
N.H. Fanaki, M.A. El-Nakeeb
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The selection of non-steroidal anti-inflammatory agents for dermal delivery
International Journal of Pharmaceutics, 2000An analysis has been conducted to show how the penetration of a selection of non-steroidal anti-inflammatory agents (NSAIDs) through the skin may be predicted. The calculations are based on physicochemical parameters that can be predicted using commercially available software.
Jeanetta du Plessis +2 more
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OBSERVATIONS ON THE INTERACTIONS BETWEEN NON‐STEROID ANTI‐INFLAMMATORY AGENTS AND CORTICOSTEROIDS*
Australasian Journal of Dermatology, 1978SummaryWe have shown that corticosteroids and non‐steroid anti‐inflammatory agents suppress the increase in skin thickness in response to irritants applied to guinea pig skin. The combination of salicylic acid with corticosteroids and acetyl salicylic acid with hydrocortisone results in an antagonistic reduction of their anti‐inflammatory activities ...
P. M. Gaylarde, A.P. Brock, I. Sarkany
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Use of non-steroidal anti-inflammatory drugs (NSAIDs) as immunomodulatory agents [PDF]
BMJ, 2013 I was delighted to see the BMJ Therapeutics series covering non-steroidal anti-inflammatory agents—a class of drugs that has perhaps been unfairly maligned and shunned recently.1 Although the article focused on the use of these drugs as analgesics, they can be used as immunomodulatory agents.
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Chapter 19. Non-steroidal Anti-inflammatory Agents
1969Publisher Summary This chapter elaborates studies analyzing non-steroidal anti-inflammatory agents. The importance of the circulating lymphocyte in association with the auto-immune component of adjuvant disease was shown by studies with heterologous antirat lymphocyte serum which prevents secondary responses to complete adjuvant. The RNA/DNA ratio of
Jan W. F. Wasley +5 more
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