Results 251 to 260 of about 96,642 (272)
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In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents
Prostaglandins, 1976In vivo effects of orally administered inhibitors on prostaglandin and F levels were determined in seven organs of the rat. Ibuprofen showed suppression in most tissues three hours after dosing with a return to control values by twenty-four hours. Flurbiprofen and indomethacin showed potent suppression at both three and twenty-four hours after dosing ...
M.A. Wynalda, F.A. Fitzpatrick
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Chapter 25. Non-steroidal Anti-inflammatory Agents
1970Publisher Summary This chapter elaborates the development and clinical studies of nonsteroidal anti-inflammatory agents. The studies of the possible role of infectious inductions and/or adverse immunological reactions continue with the hope of defining the trigger mechanism for the chronic and self-perpetuating inflammatory processes in man.
Jan W. F. Wasley +5 more
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Metabolic disposition of the non-steroidal anti-inflammatory agent isoxicam in man
European Journal of Drug Metabolism and Pharmacokinetics, 1992The metabolic fate of isoxicam, a long half-life non-steroidal anti-inflammatory agent, in human subjects was investigated using isoxicam labelled with 14C in the N-methyl position. Three healthy male subjects were each administered a single oral 200 mg dose (90.7 microCi) with plasma and urine collected. Total plasma radioactivity peaked between 8 and
Tsun Chang +3 more
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Steroid and non-steroid anti-inflammatory agents in asthma.
The European respiratory journal. Supplement, 1989Anti-inflammatory steroids are the principal agents for the treatment of asthma. Systemic corticosteroids are recommended for the treatment of acute episodes of asthma, whereas inhaled steroids should be used in the long-term prophylaxis of asthma.
MAPP, Cristina +4 more
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Factors affecting absorption of non-steroidal anti-inflammatory agents in the horse
Veterinary Record, 1982The absorption of orally administered phenylbutazone (5 mg/kg) was studied in 10 thoroughbreds, eight ponies and four pony foals. Large variations in area under the curve (AUC) and peak plasma concentrations were found both within an animal and within groups of animals.
M Sullivan, D H Snow
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Studies on the Mode of Action of Non-Steroidal Anti-Inflammatory Agents [PDF]
, 1972 The recent proposal by Vane and his associates at the Royal College of Surgeons in London (Vane, 1971; Smith and Willis, 1971; Ferreira et al, 1971) that the antiinflammatory activity of indomethacin may be related to its ability to inhibit prostaglandin biosynthesis prompted the present studies.
F. A. KuehlJr. +4 more
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Chapter 18. Non-steroidal Anti-inflammatory Agents
1975Publisher Summary The complex nature of the inflammatory diseases accentuates the difficulty of studying the mechanism of action of anti-inflammatory agents. It has been speculated that non-steroidal antiinflammatory agents (NAA's) may exert their effects by inhibiting leucocyte migration inhibiting prostaglandin synthesis interfering with ...
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Non–steroidal anti–inflammatory agents [PDF]
Acta Anaesthesiologica Scandinavica, 1993 openaire +1 more source
Effects of flunoxaprofen, a non-steroidal anti-inflammatory agent, on the cardiovascular system.
Journal of medicine, 1992The effects of flunoxaprofen (FL) were investigated using anesthetized normotensive and spontaneously hypertensive (SHR) young and old rats. The animals were divided into two groups. One group received a non-steroidal anti-inflammatory agent at doses significantly inhibiting prostaglandin (PG)-cyclooxygenase; the other received no non-steroidal anti ...
ROSSI, Francesco +4 more
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Pharmacology and comparative toxicology of non-steroidal anti-inflammatory agents
1983Non-steroidal anti-inflammatory agents (NSAIA) are widely used drugs in human therapy and to a lesser extent in veterinary practice. They belong to many chemical classes (although most of them are organic acids) and have in common antipyretic, analgesic and anti-inflammatory activity.
G. Mazue, J. Berthe, P. Richez
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