Results 91 to 100 of about 3,620,680 (377)

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

open access: yesAdvanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu   +20 more
wiley   +1 more source

Henri Bergson et les conservateurs espagnols (1907-1940)/I

open access: yesCahiers de Civilisation Espagnole Contemporaine, 2013
The Great War hardens the relationship between France and Spanish conservatives, rather germanophile since the Revolution of 1789. The philosopher Henri Bergson, a very strong intellectual authority in his country between 1900 and 1920, enlisted as a ...
Camille Lacau Saint-Guily
doaj   +1 more source

Whitehead and Pythagoras [PDF]

open access: yes, 2006
While the appeal of scientific materialism has been weakened by developments in theoretical physics, chemistry and biology, Pythagoreanism still attracts the allegiance of leading scientists and mathematicians.
Gare, Arran
core  

Contextualism and Intellectualism [PDF]

open access: yes, 2010
This is a preprint of an article published in Philosophical Perspectives, Volume 24, Issue 1, pages 383-405, December 2010. The definitive version is available at www3.interscience.wiley.com doi: 10.1111/j.1520-8583.2010.00197.xThe main goal of this ...
McGrath, Matthew
core   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

open access: yesAdvanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao   +8 more
wiley   +1 more source

An Overview of Academic Freedom in Turkey: Re-Thinking Theory and Praxis

open access: yesInterdisciplinary Political Studies, 2017
This study will present and discuss the role of intellectuals in society through the analysis of a case of Turkey in relation to theory and praxis. The group of scholars who call themselves 'Academics for Peace' prepared and signed a petition against the
Sevgi Dogan
doaj   +1 more source

Cultures of Expertise and the Public Interventions of Economists [PDF]

open access: yes, 2013
The essays in this volume examine the economist as public intellectual. Rather than assessing the changing status of the public intellectual in culture or attempting to define the identity of the public intellectual, our approach is to study the public ...
Mata, Tiago, Medema, Steven G
core   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

open access: yesAdvanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li   +5 more
wiley   +1 more source

How Belief-Credence Dualism Explains Away Pragmatic Encroachment [PDF]

open access: yes, 2019
Belief-credence dualism is the view that we have both beliefs and credences and neither attitude is reducible to the other. Pragmatic encroachment is the view that practical stakes can affect the epistemic rationality of states like knowledge or ...
Jackson, Elizabeth
core  

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