Results 81 to 90 of about 3,620,680 (377)

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Review of Howley, Howley & Pendarvis

Education Policy Analysis Archives, 1997
Howley, Craig B., Howley, Aimee & Pendarvis, Edwina D. (1995). Out of Our Minds: Anti-Intellectualism and Talent Development in American Schooling NY, NY: Teachers College Press. Pp. 265; $24.95 (Paper)
Pat Clifford
doaj  

Das Konzept des austromarxistischen Intellektuellen

Österreichische Zeitschrift für Geschichtswissenschaften, 1990
The overriding topic of the author's scholarly interest in connection with this article was the concept of the so called (Austromarxist) ,,Leftist Intellectual" who is considered as a particular „cultural type" (Kulturtypus).
Alfred Pfabigan
doaj   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Backlash Politics and Contempt for Truth and Knowledge

Revue Internationale des Études du Développement
This article contributes to current understanding of backlash politics by analyzing parliamentary speeches and social media posts by Jair Bolsonaro on his path to the Brazilian presidency (2010-2018).
Allan Santos
doaj   +1 more source

Scientifically based research in a post-truth era

Education Policy Analysis Archives, 2018
In this article, I explore the tension between the current political context in which science needs defending against anti-intellectualism and outright assaults on evidence as a means of decision-making on the one hand and the overzealous scientism that ...
Jessica Van Cleave
doaj   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Epistemological and ethical assessment of obesity bias in industrialized countries

Philosophy, Ethics, and Humanities in Medicine, 2011
Bernard Lonergan's cognitive theory challenges us to raise questions about both the cognitive process through which obesity is perceived as a behaviour change issue and the objectivity of such a moral judgment.
Azétsop Jacquineau, Joy Tisha R
doaj   +1 more source

Let’s get anti-intellectual

, 2018
Der einleitende Texte gibt einen Überblick über aktuelle theoretische Tendenzen, Materialität zu erforschen. Dabei stehen besonders solche Ansätze im Mittelpunkt, die das Verhältnis zur Kunst, vor allem in ihren jeweiligen Produktionskontexten, ästhetisch-gestalterischen Prozessen und Praktiken sowie ihren Wissenspotenzialen verhandeln.
openaire   +3 more sources