Results 171 to 180 of about 2,473,972 (271)
Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion
Advanced Science, EarlyView.Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping +4 more
wiley +1 more source
Rewilding: history, intervention and the quest for immanence. [PDF]
Hist Philos Life SciValverde Pérez N, Castro García Ò.
europepmc +1 more source
Advanced Science, EarlyView.Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao +8 more
wiley +1 more source
Cold war of strains: the 'Bulgarian' BCG vaccine between Paris, Copenhagen, and Moscow (1940s-1950s). [PDF]
Med HistAngelova M.
europepmc +1 more source
RUNX1‐Mediated Hypoxic Signaling Impairs Myogenesis and Promotes Fibrosis in Myopathies
Advanced Science, EarlyView.Myofiber overgrowth was associated with reduced blood flow and a potential hypoxic state in broiler breast muscle, accompanied by increased RUNX1 expression. Elevated RUNX1 impaired myogenic regeneration, promoted fibrosis, and disrupted the signaling niche required for efficient muscle repair, contributing to pathological degeneration in Wooden Breast
Liang Zhao +4 more
wiley +1 more source
Intelligent Polymer Electrolytes for Next‐Generation Zinc‐Based Energy Storage Devices
Advanced Science, EarlyView.Intelligent polymer electrolytes are organized into a three‐level hierarchy that advances zinc‐based energy storage from passive ion conduction toward active, adaptive, and intelligent operation. Molecular regulation of Zn+ coordination, water activity, desolvation, ion flux, and interfaces underpins adaptive self‐healing, anti‐freezing, adhesion, and ...
Sanath Kumar +4 more
wiley +1 more source
Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning
Advanced Science, EarlyView.Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin +13 more
wiley +1 more source
Who's afraid of the political novel? An introduction. [PDF]
Open Res EurPerica I, Peyroles A.
europepmc +1 more source
Advanced Science, EarlyView.When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu +5 more
wiley +1 more source