Results 191 to 200 of about 951 (249)

Parkinson's Disease Patient‐Specific Striatum Organoids Show Hallmarks of Increased Inflammation

Movement Disorders, EarlyView.
Abstract Background Dopaminergic neurons from the substantia nigra pars compacta project their axons into the dorsal striatum, forming the nigrostriatal pathway. In Parkinson's disease (PD), dopaminergic terminals degenerate in the striatum, leading to dopamine depletion, which in turn causes alterations in the basal ganglia circuits that are essential
Kyriaki Barmpa, Claudia Saraiva, Alise Zagare, Mona Tuzza, Joseph Longworth, Elisa Zuccoli, Katrin Hufnagel, Florian Skwirblies, Ronny Schmidt, Dirk Brenner, Christoph Schröder, Jens C. Schwamborn   +11 more
wiley   +1 more source

Scientific highlights of the 8th world one health Congress, Cape Town, South Africa 2024. [PDF]

One Health Outlook
Reperant L, Mackenzie J, Venter M, Mulumba M, Osterhaus A.   +4 more
europepmc   +1 more source

Navigating the Rapids: How Non‐Governmental Organization Managers Develop Strategic Adaptation to Repressive Political Environments

Public Administration and Development, EarlyView.
ABSTRACT This article explores the management adaptation strategies non‐governmental organizations (NGOs) managers employ in order to operate in repressive political environments. It answers the question: how do NGO managers initiate, manage and sustain internal change when the political/regulatory environment changes?
Charles Kaye‐Essien, Shahjahan Bhuiyan, Ghadeer Ali   +2 more
wiley   +1 more source

Efficacy of Bacillus Calmette-Guérin in Cancer Prevention and Its Putative Mechanisms. [PDF]

J Cancer Prev
Gupta S, Yadav S, Kumar P.
europepmc   +1 more source

Rethinking Public Administration Reform: Institutional Layering of Bureaucratic, Managerial and Community Logics Over Time in Nigeria's Tax Administration

Public Administration and Development, EarlyView.
ABSTRACT The reform of public institutions has attracted sustained attention in both scholarship and policymaking. Increasingly, however, there is growing recognition that reforms are rarely implemented in an institutional vacuum. Instead, new reforms are layered onto existing arrangements, producing hybrid institutional landscapes shaped by prior ...
Edidiong Bassey
wiley   +1 more source

How dispositional optimism-pessimism relates to early adolescents' emotional maladjustment during COVID-19? Moderating roles of knowledge about the disease and parent-child conflicts. [PDF]

Front Psychiatry
Jiang Y, Wu D, Lin X.
europepmc   +1 more source

Views from the hill: Deer stalkers' perspectives on land‐use change in the Scottish Highlands

People and Nature, EarlyView.
Abstract Land‐use and wildlife management are changing globally as part of efforts to address contemporary environmental challenges. In the Scottish Highlands, the hunting—or ‘stalking’—of deer has entered a period of considerable flux primarily because of national policy changes to mitigate climate change and biodiversity loss.
Callum Leavey‐Wilson, Janet A. Fisher, Sam Staddon   +2 more
wiley   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Mapping the Research Landscape of the Correlation Between Radiotherapy and Tumor Immune Microenvironment: A Bibliometric Analysis

Precision Radiation Oncology, EarlyView.
The first bibliometric analysis of 2,584 articles revealed studies led by China on radiotherapy and tumor immune microenvironment. The analysis concluded that the research in this field has gone through three stages: mechanism exploration, clinical validation, and technological and personalized optimization.
Shangyi Geng, Xia Li, Yongze Dang, Xinran Huang, Lintao Zhang, Xinyu He, Shupei Pan, Hongbing Ma, Xixi Zhao   +8 more
wiley   +1 more source

Lecanicillium aphanocladii: a biocontrol agent against insect pests and phytopathogens

Pest Management Science, EarlyView.
Recent research findings on the biocontrol potential of Lecanicillium aphanocladii fungus against insect‐pests and plant diseases were highlighted. This review indicates that several L. aphanocladii strains show great potential to be developed as multipurpose biocontrol agents active against several insect‐pests, plant diseases and plant parasitic ...
Qianhe Liu, Richard Johnson, Kwasi Adusei‐Fosu   +2 more
wiley   +1 more source