Results 31 to 40 of about 549 (251)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

ANTI-PROVERB AS A TYPE OF INTERTEXTUAL JOKE1

open access: yesHUMANITAS - Uluslararası Sosyal Bilimler Dergisi, 2018
Intertextuality is one of the most complicated disciplines of literary studies, which a large number of theorists have attempted to define; still, the definitions greatly differ from each other in terms of their focal points. Whilst some scholars such as Rifaterre (1994) and Barthes (2001) emphasize the role of readers and reading process in the ...
openaire   +4 more sources

TOWARDS A LINGUISTIC ANALYSIS OF SUBSTITUTION IN ANGLO-AMERICAN ANTI-PROVERBS ABOUT MONEY

open access: yesProverbium
The recent study is to be seen as a continuation of the author's previous research (conducted alone or with co-authors) which is concerned with the study of various techniques of proverb transformation.
Anna T. Litovkina
doaj   +1 more source

Michael Scott’s anti-proverbs and pseudo-proverbs as a source of humour in The Office

open access: yesThe European Journal of Humour Research, 2023
This article analyses the use of proverbs in the American version of the sitcom The Office, especially in relation to Michael Scott, the show’s main protagonist.
Luis J. Tosina Fernández
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

LABOR in the Paradigm of the Values of European and Asian Peoples: on the Basis of Russian, French and Kalmyk Proverbs

open access: yesRUDN Journal of Language Studies, Semiotics and Semantics, 2023
The paremiological fund of language either explicitly or implicitly expresses information about the value system of the people. The study is devoted to the description of labor as a value of European and Asian peoples on the basis of paremiological ...
Natalia Yu. Neliubova   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

The Humanistic Value of Proverbs in Sociopolitical Discourse

open access: yesHumanities, 2018
Proverbs as strategic signs for recurrent situations have long played a significant communicative role in political rhetoric. Folk proverbs as well as Bible proverbs appear as expressions of wisdom and common sense, adding authority and didacticism to ...
Wolfgang Mieder
doaj   +1 more source

Proverbs, Anti-Proverbs and Language Learning

open access: yesStudies in English Language Teaching, 2017
<p class="Abstract"><em>Proverbs express public wisdom and reflect public attitudes. In the traditional definition they are untouchable when it comes to form. Like other idiomatic expressions, they are learnt as whole, indivisible chunks. As such, they should be included in language classes, if a native-like mastery is to be achieved since ...
Sana’ Ababneh   +1 more
openaire   +2 more sources

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