Results 211 to 220 of about 1,262 (267)

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity. [PDF]

Nature
Nicola PA, Lawson ARJ, Tidd A, Imbert J, Ishida Y, Wylie LA, Scott PA, Roberts K, Harvey LMR, Lensing SV, Cheng W, Abascal F, Leongamornlert D, Hooks Y, Mayho M, Müller-Sienerth N, Widaa S, Mincarelli L, Illing J, Peci F, Ng BL, Jarman GL, Russell AJC, Mahbubani KTA, Saeb-Parsy K, Paterson AL, Chatterjee K, Rahbari R, Bayraktar OA, Stratton MR, Campbell PJ, Tadross JA, Schoenmakers N, Martincorena I.   +33 more
europepmc   +1 more source

Bridged h‐BN Nanosheets Coatings: Simultaneous Shielding Atomic‐Oxygen Irradiation and Achieving Superior Friction Performance

Advanced Science, EarlyView.
ABSTRACT To confront extreme space environments, a combination of inorganic and organic coatings can provide a pathway for offering highly durable radiation resistance and anti‐friction simultaneously. Herein, a strong interfacial 3D hydrogen‐bonding network is designed to create robust hexagonal boron nitride (h‐BN) based polymer coatings with ...
Zhuoyi Li, Changning Bai, Xingkai Zhang, Yusheng Liang, Wei Wu, Dingrui Zhou, Tao Du, Chunjin Wang   +7 more
wiley   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Effect of suction stress on the strength of rupture zone and stability of landslide. [PDF]

Sci Rep
Wang J, Su A, Liu Q, Zou Z.
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Elementary 3D organization of active and silenced E. coli genome. [PDF]

Nature
Gavrilov AA, Shamovsky I, Zhegalova I, Proshkin S, Shamovsky Y, Evko G, Epshtein V, Rasouly A, Blavatnik A, Lahiri S, Rothenberg E, Razin SV, Nudler E.   +12 more
europepmc   +1 more source

Comparative discriminant analysis of Mesua ferrea L. and its adulterants. [PDF]

Heliyon
Kuerban M, Ma F, Shan L, Wang Y, Zhou G.
europepmc   +1 more source

Effect of Semen Collection in the Metabolite and Hormonal Content of Rabbit Seminal Plasma. [PDF]

Vet Med Sci
Álvarez-Rodríguez M, García-Calvo L, Gardela J, Ruiz-Conca M, Olvera-Maneu S, Martín-San Juan A, López-Béjar M, Martinez-Pastor F, Vicente-Carrillo A.   +8 more
europepmc   +1 more source

Immunopathological Changes Caused by <i>Oesophagostomum radiatum</i> in Calves: Insights into Host-Parasite Interactions. [PDF]

Pathogens
Bassetto CC, Albuquerque ACA, Lins JGG, Canalli GFD, Gomes AKDS, Amarante AFT.   +5 more
europepmc   +1 more source