Results 101 to 110 of about 1,438,843 (259)

A strict statism for motivating reasons

open access: yes
Practical motivating reasons are the reasons in light of which an agent acts. This paper aims to defend the thesis that practical motivating reasons are obtaining states of affairs. This conception can be called strict statism.
Molina, Yohan
core   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

open access: yesAdvanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu   +9 more
wiley   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

open access: yesAdvanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding   +13 more
wiley   +1 more source

Cold War Governance: The State That Anti-Statism Built in Postwar America

open access: yesSocial Science History
Abstract Wars make states, but the conclusion of conflict is critical for the trajectory of state-building that follows. At the end of World War II, both conservatives and progressives in the United States recognized the potential for ongoing statist development fueled by the wartime introduction of mass taxation and the expansion of ...
openaire   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

open access: yesAdvanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau   +22 more
wiley   +1 more source

Fallen Behind: Science, Technology and Soviet Statism

open access: yes, 2015
Why, despite the overwhelming enthusiasm from the state for science and technology, did the Soviet Union fail in its project of modernization? This essay argues that the fundamental reason behind the Soviet Union\u27s technological lag, and its ...
Chan, Chi Ling
core  

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

open access: yesAdvanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas   +13 more
wiley   +1 more source

Annual report of Anti-Saloon League of Oregon for fiscal year ending

open access: yes
Title varies slightly.1922 lacks title.This archived document is maintained by the State Library of Oregon. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the State Library of Oregon Oregoniana ...

core  

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