Results 31 to 40 of about 867,316 (264)

Key Stages in the Development of SAET Laboratory Facilities

Проблемы особо опасных инфекций, 2014
Considered are the stages of the SAET laboratory facilities development. Initially main area of activities was assumed to be specific indication of bacterial threats and laboratory control over the ambient environment objects for the presence of ...
S. A. Portenko, S. A. Shcherbakova, E. S. Kazakova, I. N. Sharova, I. G. Karnaukhov, A. V. Toporkov, V. V. Kutyrev   +6 more
doaj   +1 more source

MANAGEMENT OF ANTI-CRISIS MANAGEMENT OF ENTERPRISES

Market Infrastructure
The article considers different approaches to understanding financial planning, highlights its importance as a tool for reducing financial risks and ensuring the financial stability of the enterprise. Special attention is paid not only to profitability forecasting, but also to factors affecting solvency and capital structure. The article also describes
Olena Smetaniuk, Yuriy Karpinskyi
openaire   +1 more source

METHOTREXATE INTOXICATION IN THE ELDERLY POPULATION: A REPORT OF TWO CASES

Anti-Aging Eastern Europe
Methotrexate (MTX), a folate antagonist, is the anchor drug in rheumatoid arthritis (RA) treatment. The low dose is the most preferred therapeutic management, considered safe and generally well-tolerated in many rheumatic patients.
Mesut Ajder, Reşit Yildirim, Döndü Üsküdar Cansu, Cengiz Korkmaz   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Usage of Mobile Laboratories of Biological Expertise Abroad and in Russia: Present Day Realities and Prospects

Проблемы особо опасных инфекций, 2018
We analyzed the data on availability and usage of mobile laboratories of biological expertise for indication and identification of pathogenic biological agents in foreign countries and in the Russian Federation.
I. G. Karnaukhov, I. N. Sharova, E. S. Kazakova, K. M. Morozov, S. A. Shcherbakova, V. V. Kutyrev   +5 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Geriatric oncology: problems with under-treatment within this population

Cancer Biology & Medicine, 2015
We are currently faced with an aging population, which is rapidly growing worldwide. Two thirds of cancer occurs in the over 65-year age group. Societal conceptions from the past have created ageist stereotypes; old age is associated with frailty and the
Divya Swaminathan, Vikram Swaminathan
doaj   +1 more source

Risk Management in the Context of the Anti-Crisis Management Strategy

Economics: time realities, 2023
It has been established that risk management in the context of an anti-crisis management strategy is an important aspect for ensuring the stability and success of an organization in the face of negative events and crisis situations. difficult conditions. It is emphasized that the development and justification of the company's anti-crisis strategy is an
Vasilieva, Lesja, Zemlany, Maxim
openaire   +2 more sources

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source