Repositioning of antiarrhythmics for prostate cancer treatment: a novel strategy to reprogram cancer-associated fibroblasts towards a tumor-suppressive phenotype [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Cancer-associated fibroblasts (CAFs) play a significant role in fueling prostate cancer (PCa) progression by interacting with tumor cells. A previous gene expression analysis revealed that CAFs up-regulate genes coding for voltage-gated cation
Valentina Doldi +8 more
doaj +3 more sources
Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines [PDF]
Journal of Pharmacology and Experimental Therapeutics, 2019 Class II antiarrhythmics or β-blockers are antisympathetic nervous system agents that act by blocking β-adrenoceptors. Despite their common clinical use, little is known about the effects of β-blockers on free intracellular calcium (Ca2+i), an important ...
Marta Reyes-Corral +5 more
semanticscholar +2 more sources
JCI Insight, 2021 Native myocardial voltage-gated sodium (NaV) channels function in macromolecular complexes comprising a pore-forming (α) subunit and multiple accessory proteins.
Wandi Zhu +6 more
semanticscholar +3 more sources
Antiarrhythmics in Cardiac Arrest: A Systematic Review and Meta-Analysis.
Heart, Lung and Circulation, 2017 Introduction: It is widely accepted that antiarrhythmics play a role in cardiopulmonary resuscitation (CPR) universally, but the absolute benefit of antiarrhythmic use and the drug of choice in advanced life support remains controversial. Aim: To perform
A. Chowdhury +3 more
semanticscholar +2 more sources
Antiarrhythmics After Ablation of Atrial Fibrillation (5A Study): Six-Month Follow-Up Study
Circulation: Arrhythmia and Electrophysiology, 2011 Background— We previously demonstrated that treatment with antiarrhythmic drugs (AADs) during the first 6 weeks after atrial fibrillation (AF) ablation reduces the incidence of clinically significant atrial arrhythmias and need ...
P. Leong-Sit +14 more
semanticscholar +2 more sources
Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants
The Journal of General Physiology, 2017 Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels. Prior studies have revealed a common drug-binding region within the pore, but details about the binding ...
D. Tikhonov, B. Zhorov
semanticscholar +2 more sources
Efficacy of class III antiarrhythmics and magnesium combination therapy for atrial fibrillation
Pharmacy in practice, 2012 Atrial fibrillation is a common cardiac arrhythmia, and has been a significant financial burden. Class III antiarrhythmics such as dofetilide, ibutilide, and amiodarone are indicated for rhythm control.
Amy Wang
semanticscholar +3 more sources
Causes of death in the Antiarrhythmics Versus Implantable Defibrillators (AVID) Trial.
Journal of the American College of Cardiology, 1999 OBJECTIVESThis study analyzed the causes of death in the Antiarrhythmics Versus Implantable Defibrillators (AVID) Trial.BACKGROUNDBoth implantable cardioverter-defibrillators (ICDs) and antiarrhythmic drugs (AADs) are used as mainstays of treatment for ...
D. Richardson +16 more
semanticscholar +3 more sources
Pharmacoepidemiology and Drug Safety, 2021 To compare risks of interstitial lung disease (ILD) between patients treated with dronedarone versus other antiarrhythmics.
A. Tave +9 more
semanticscholar +1 more source
R-wave double counting secondary to antiarrhythmics and ablation leads to unnecessary shock
HeartRhythm Case Reports, 2020 During tachyarrhythmia, class I antiarrhythmics Introduction A 61-year-old man with recurrent ventricular tachycardia (VT) and dual-chamber implantable cardiac defibrillator (ICD) was evaluated following a shock and syncope.
Madhurima Home +4 more
semanticscholar +1 more source