Results 71 to 80 of about 783,534 (199)

Synthesis and Structure–Activity Relationship Study of 2-(amino)quinazolin-4(3H)-one Derivatives as Potential Inhibitors of Methicillin-Resistant Staphylococcus aureus (MRSA)

Antibiotics
Background/Objectives: The rise in methicillin-resistant Staphylococcus aureus (MRSA) demands new therapeutic strategies. In this study, a series of 2-(amino)quinazolin-4(3H)-one derivatives were synthesized and evaluated for antistaphylococcal activity.
Jun Young Lee, Hyunjung Lee, Sungmin Kim, Jihwan Gim, Yunmi Lee, Chae Jo Lim, Hyun-Seob Song, Hyeung-geun Park, Soojin Jang, Chul Min Park   +9 more
doaj   +1 more source

Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids [PDF]

, 2015
We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids.
Agata Paneth, Aleksandra Strzelczyk, Anna Malm, Barbara Kaproń, Barbara Rajtar, Dalhoff, Małgorzata Polz-Dacewicz, Oliphant, Paweł Stączek, Sharma, Tomasz Plech, Urszula Kosikowska, Łukasz Świątek   +12 more
core   +2 more sources

Advancing Pediatric Antibacterial Drug Development: A Critical Need to Reinvent our Approach. [PDF]

, 2019
The Clinical Trials Transformation Initiative convened with several groups in the pediatric antibacterial drug development community with the goal of identifying challenges and recommending ways to improve current practice.
Bradley, John, Clinical Trials Transformation Initiative’s Pediatric Antibiotic Drug Development Program, Nambiar, Sumathi, Noel, Gary J   +3 more
core   +1 more source

Biofunctional coatings and drug-coated stents for restenosis therapy

Materials Today Bio
Palliative therapy utilizing interventional stents, such as vascular stents, biliary stents, esophageal stents, and other stents, has been a prevalent clinical strategy for treating duct narrowing and partial blockage.
Yanghui Wen, Yihuan Li, Rui Yang, Yunjie Chen, Yan Shen, Yi Liu, Xiaomei Liu, Botao Zhang, Hua Li   +8 more
doaj   +1 more source

Evaluation of antibacterial activity of Pisidium guajava and Gongronema Latifolium [PDF]

, 2008
Pisidium guajava and Gongronema latifolium are local plants used traditionally in south-eastern Nigeria to treat ailments such as cough, loss of appetite, malaria and stomach disorders. In this study, aqueous and ethanolic leaf extracts of P. guajava and
Ajani, O. O., Chinedu, S. N., Nwinyi, O. C.   +2 more
core  

Rapid Quantification of Ceftobiprole in Human Plasma and Cerebrospinal Fluid by LC-MS/MS and Its Application in Patients with Central Nervous System Infections

Molecules
Ceftobiprole is a fifth-generation beta-cephalosporin with high inter-individual pharmacokinetic variability in critically ill patients. However, data on its pharmacokinetics and central nervous system (CNS) penetration are limited.
Sabahat Ablimit, Wanzhen Li, Mengting Chen, Jing Zhang, Nanyang Li, Yaxin Fan, Muyassar Yasen, Mubarak Iminjan, Beining Guo   +8 more
doaj   +1 more source

The Application of Bactericidal Silver Nanoparticles in Wound Treatment

Nanomaterials and Nanotechnology, 2015
Even with the prevalence of wounds, the medical technol‐ ogy for efficiently managing skin damage is still primitive. The disruption of any of the numerous healing processes can lead to problems in the time-sensitive healing actions of the dermal and ...
Geewoo Nam, Sabarinathan Rangasamy, Baskaran Purushothaman, Joon Myong Song   +3 more
doaj   +1 more source

The Prevalence of Antibiotic and Toothpaste Sensitivity Found in Oral Streptococcal Isolates in Healthy Individuals in the Okada Community of Nigeria [PDF]

, 2017
Background: This study aimed to determine the prevalence, antibiotic, and toothpaste sensitivity of oral streptococcal isolates in healthy individuals in the Okada community of Nigeria.
Mitsan, O. (Olley), Okwu, M. U. (Maureen)   +1 more
core  

Classification Framework and Structure-Activity-Relationship (SAR) of Tetracycline-Structure-Based Drugs

, 2012
By studying the literature about Tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are known, especially against bacteria, while against other targets, they are
Bortolotto, Carlotti, Chen, Chopra, De Luigi, Doershuk, Duivenvoorden, Dutta, Lambs, McNamara, Nelson, Nelson, Silvia, Stetler-Steveson, Tang, Thong, Wainwright, Yrjanheikki   +17 more
core   +2 more sources

Discovery of pyridomycin derivatives as InhA inhibitors from actinomycetes through molecular networking and an In-House tandem mass library

Natural Products and Bioprospecting
A screen of ~ 4000 actinomycetes strains identified Streptomyces sp. W3009 as a producer of the antituberculosis agent pyridomycin. Using a mass spectrometry-based metabolomics approach coupled with molecular networking, we identified seven pyridomycin ...
Byeongsan Lee, Gwi Ja Hwang, Jun-Pil Jang, Beomcheol Park, Juhee Won, Sun Young Kim, Minjeong Woo, Connor Wood, Bang Yeon Hwang, Jae-Hyuk Jang, Young-Soo Hong   +10 more
doaj   +1 more source