Results 131 to 140 of about 171,459 (261)

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source

Proteomic Insights into the Antibacterial Mechanism of Brevibacillus brevis HK544 Producing Edeine B1 against Erwinia amylovora. [PDF]

Plant Pathol J
Kim YS, Rhyu H, Kim B, Van Nguyen M, Han JW, Choi GJ, Son H, Han SW, Kim H.   +8 more
europepmc   +1 more source

Antibacterial activity and antibacterial mechanism of flavaspidic acid BB against Staphylococcus haemelyticus. [PDF]

BMC Microbiol, 2023
Liu J, Liu R, Deng R, Zheng S, Shen Z.
europepmc   +1 more source

Mechanisms of Antibacterial Resistance

, 2017
ROSSOLINI, GIAN MARIA, ARENA, FABIO, GIANI, TOMMASO   +2 more
openaire   +3 more sources

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Antibacterial Mechanism of Allicin E Against <i>Aeromonas hydrophila</i> and Therapeutic Effect in <i>Carassius auratus gibelio</i>. [PDF]

Antibiotics (Basel)
Li J, Lu L, Chen K, Qin T, Xie J, Fang P, Xi B.   +6 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Proteomics and acetyl-proteomics reveal the antibacterial mechanism of berberine sulfate against methicillin-resistant Staphylococcus aureus. [PDF]

Front Microbiol
Hu Z, Liu H, Chen M, Zhou J, Bian Y, Lin C, Liu S, Sun Y, Tan M, Xu JY.   +9 more
europepmc   +1 more source

Transcriptomic analyses reveal the potential antibacterial mechanism of citral against Staphylococcus aureus. [PDF]

Front Microbiol, 2023
Liao Z, Lin K, Liao W, Xie Y, Yu G, Shao Y, Dai M, Sun F.   +7 more
europepmc   +1 more source

Mechanisms of antibacterial resistance

, 2010
Franz-Josef Schmitz, Ad C Fluit
openaire   +1 more source