Results 161 to 170 of about 529,151 (288)
CH50 as a Clinically Useful Biomarker of Disease Activity and Antihistamine Resistance in Chronic Spontaneous Urticaria: An Observational Ambispective Single‐Center Study
International Journal of Dermatology, Volume 65, Issue 10, Page 2066-2073, October 2026.Personalized CSU care guided by CH50. ABSTRACT Background
Chronic spontaneous urticaria (CSU) is frequently refractory to guideline‐based therapy, highlighting the need for predictive biomarkers. Dysregulation of the complement system has been implicated in CSU severity, but global complement activity has not been systematically evaluated.Nidia Planella‐Fontanillas, Emilio Berna‐Rico, David Pesqué, Evelyn Andrades, Silvia Sánchez, Paloma Torres‐Bosó, Ramon Gimeno, Fernando Gallardo, Ramon M. Pujol, Ana M. Giménez‐Arnau +9 morewiley +1 more sourceA Genetic Risk Variant Associated With the Risk of Primary Biliary Cholangitis Is Inherited From Neanderthals
Liver International, Volume 46, Issue 10, October 2026.ABSTRACT Background
Primary Biliary Cholangitis (PBC) is an autoimmune cholangiopathy with polygenic architecture and unknown aetiology. Evidence links Neanderthal‐derived genetic variants to autoimmune conditions; however, their contribution to PBC susceptibility remains unexplored.Alessio Gerussi, Chiara Caime, Harold Wang, Heather J. Cordell, George F. Mells, Richard N. Sandford, David E. Jones, Gideon Hirschfield, Katherine A. Siminovitch, M. Eric Gershwin, Brian D. Juran, Elizabeth J. Atkinson, Angela Cheung, Mariza de Andrade, Aris Baras, Konstantinos N. Lazaridis, Rosanna Asselta, Pietro Invernizzi, Manuela Sironi, Sriram Sankararaman, Canadian‐US PBC Consortium, UK‐PBC Consortium, James J. Fryett, Rebecca Darlay, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Richard Sturgess, Christopher Healey, Andrew Yeoman, Anton Vj Gunasekera, Paul Kooner, Kapil Kapur, V. Sathyanarayana, Yiannis Kallis, Javaid Subhani, Rory Harvey, Roger McCorry, Paul Rooney, David Ramanaden, Richard Evans, Thiriloganathan Mathialahan, Jaber Gasem, Christopher Shorrock, Mahesh Bhalme, Paul Southern, Jeremy A. Tibble, David A. Gorard, Susan Jones, Brijesh Srivastava, Matthew R. Foxton, Carole E. Collins, David Elphick, Mazn Karmo, Francisco Porras‐Perez, Michael Mendall, Tom Yapp, Minesh Patel, Roland Ede, Joanne Sayer, James Jupp, Neil Fisher, Martyn J. Carter, Konrad Koss, Jayshri Shah, Andrzej Piotrowicz, Glyn Scott, Charles Grimley, Ian R. Gooding, Simon Williams, Judith Tidbury, Guan Lim, Kuldeep Cheent, Sass Levi, Dina Mansour, Matilda Beckley, Coral Hollywood, Terry Wong, Richard Marley, John Ramage, Harriet M. Gordon, Jo Ridpath, Theodore Ngatchu, Vijay Paul Bob Grover, Ray G. Shidrawi, George Abouda, L. Corless, Mark Narain, Ian Rees, Ashley Brown, Simon Taylor‐Robinson, Joy Wilkins, Leonie Grellier, Paul Banim, Debasish Das, Michael A. Heneghan, Howard Curtis, Helen C. Matthews, Faiyaz Mohammed, Mark Aldersley, Raj Srirajaskanthan, Giles Walker, Alistair McNair, Amar Sharif, Sambit Sen, George Bird, Martin I. Prince, Geeta Prasad, Paul Kitchen, Adrian Barnardo, Chirag Oza, Nurani N. Sivaramakrishnan, Prakash Gupta, Amir Shah, Chris Dj Evans, Subrata Saha, Katharine Pollock, Peter Bramley, Ashis Mukhopadhya, Stephen T. Barclay, Natasha McDonald, Andrew J. Bathgate, Kelvin Palmer, John F. Dillon, Simon M. Rushbrook, Robert Przemioslo, Chris McDonald, Andrew Millar, Cheh Tai, Stephen Mitchell, Jane Metcalf, Syed Shaukat, Mary Ninkovic, Udi Shmueli, Andrew Davis, Asifabbas Naqvi, Tom Jw Lee, Stephen Ryder, Jane Collier, Howard Klass, Matthew E. Cramp, Nichols Sharer, Richard Aspinall, Deb Ghosh, Andrew C. Douds, Jonathan Booth, Earl Williams, Hyder Hussaini, John Christie, Steven Mann, Douglas Thorburn, Aileen Marshall, Imran Patanwala, Aftab Ala, Julia Maltby, Ray Matthew, Chris Corbett, Sam Vyas, Saket Singhal, Dermot Gleeson, Sharat Misra, Jeff Butterworth, Keith George, Tim Harding, Andrew Douglass, Harriet Mitchison, Simon Panter, Jeremy Shearman, Gary Bray, Michael Roberts, Graham Butcher, Daniel Forton, Zahid Mahmood, Matthew Cowan, Debashis Das, Chin Lye Ch'ng, Mesbah Rahman, Gregory C. A. Whatley, Emma Wesley, Aditya Mandal, Sanjiv Jain, Stephen P. Pereira, Mark Wright, Palak Trivedi, Fiona H. Gordon, Esther Unitt, Altaf Palejwala, Andrew Austin, Vishwaraj Vemala, Allister Grant, Andrew D. Higham, Alison Brind, Ray Mathew, Mark Cox, Subramaniam Ramakrishnan, Alistair King, Simon Whalley, Jocelyn Fraser, S. J. Thomson, Andrew Bell, Voi Shim Wong, Richard Kia, Ian Gee, Richard Keld, Rupert Ransford, James Gotto, Charles Millson, Italian PBC Genetics Study Group, Andrea Affronti, Maurizia Brunetto, Barbara Coco, Giancarlo Spinzi, Gianfranco Elia, Carlo Ferrari, Ana Lleo, Luigi Muratori, Paolo Muratori, Piero Portincasa, Agostino Colli, Savino Bruno, Guido Colloredo, Francesco Azzaroli, Pietro Andreone, MariaConsiglia Bragazzi, Domenico Alvaro, Vincenzo Cardinale, Nora Cazzagon, Annarosa Floreani, Cristina Rigamonti, Floriano Rosina, Marco Carbone, Laura Cristoferi, Marco Festa, Eugenia Nofit, Miki Scaravaglio, Daphne D'Amato, Federica Malinverno, Pietro Lampertico, Francesca Donato, Stefano Fagiuoli, Piero L. Almasio, Edoardo Giannini, Carmela Cursaro, Massimo Colombo, Luca Valenti, Luca Miele, Angelo Andriulli, Grazia A. Niro, Ignazio Grattagliano, Lorenzo Morini, Giovanni Casella, Maria Vinci, Pier Maria Battezzati, Andrea Crosignani, Massimo Zuin, Alberto Mattalia, Vincenza Calvaruso, Silvia Colombo, Antonio Benedetti, Marco Marzioni, Andrea Galli, Fabio Marra, Mirko Tarocchi, Antonio Picciotto, Filomena Morisco, Luca Fabris, Lory Saveria Crocè, Claudio Tiribelli, Pierluigi Toniutto, Mario Strazzabosco +269 morewiley +1 more sourceRheumatologic Manifestations of Patients With Type B Insulin Resistance
Arthritis Care &Research, Volume 78, Issue 9, Page 1195-1200, September 2026.Objective
The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown +4 morewiley +1 more sourceClinical Phenotypes, Treatment, and Outcomes of Rheumatic Immune–Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitors: A Rheumatologists‐Referred Multicenter German Registry Cohort
ACR Open Rheumatology, Volume 8, Issue 9, September 2026.Objective
Immune checkpoint inhibitors (ICIs) induce a broad range of immune‐related adverse events (irAEs), including rheumatic manifestations. Evidence from dedicated rheumatology cohorts on the clinical spectrum, severity, treatment, and outcomes of rheumatic irAEs (rh‐irAEs) remains limited.Didzis Gailis, Fabian T.H. Ullrich, Sophia Dombret, Marc Schmalzing, Rebecca Hasseli‐Fräbel, Torsten Witte, Thea Thiele, Uta Kiltz, Mara Oleszowsky, Marcel Müller, Karolina Gente, Christof Specker, Matthias B. Thaler, Alla Skapenko, Hendrik Schulze‐Koops +14 morewiley +1 more sourceTWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays
Arthritis &Rheumatology, Volume 78, Issue 9, Page 1892-1906, September 2026.Objective
Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo +12 morewiley +1 more source
