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The Clinical Significance of Antinuclear Antibodies
Postgraduate Medicine, 1973A number of different types of antinuclear antibodies have been characterized, and their clinical significance is beginning to become clear. The anti-DNA type correlates closely with renal injury and severity of clinical disease in systemic lupus erythematosus. Antiribonucleoprotein appears to be related to mixed connective tissue disease.
Eng M. Tan +2 more
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Absorption of serum antinuclear antibodies
Clinical Immunology and Immunopathology, 1979Abstract The absorption out of antinuclear antibody (ANA) from sera of highly ANA-positive C57BL/6 mice was obtained by different cellular and noncellular factors. A single injection of DNA, liver nuclei, thymocytes, or repeated injections of a soluble material produced by normal mouse splenocytes with (SIRS+) or without (SIRS−) previous stimulation ...
David Geltner, Alpha Peled
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Antinuclear Antibodies in Multiple Sclerosis
Archives of Neurology, 1982Low levels of antinuclear antibodies (ANAs) were found by indirect immunofluorescence in the serum of patients with multiple sclerosis (MS). Antibodies were found in 22 (81%) of 27 patients with MS and four (20%) of 20 healthy control subjects, with human epithelial (HEp-2) cells as substrate. Antinuclear antibody titers ranged from 8 to 32 in patients
Robert B. Zurier +3 more
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Antinuclear antibodies in psychiatric patients
Acta Psychiatrica Scandinavica, 1994To investigate whether unrecognized systemic lupus erythematosus (SLE) might occur more frequently among psychiatric patients than expected on clinical examination, sera of 100 patients from a psychiatric hospital were tested for the presence of antibodies against nuclear antigens (ANA) and antibodies against DNA.
Ferdinand C. Breedveld +2 more
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Antinuclear Antibodies and Propylthiouracil Therapy
JAMA: The Journal of the American Medical Association, 1972To the Editor.— Drugs that have been reported to activate systemic lupus erythematosus (SLE) can be divided into those that do so by their own pharmacologic properties, and thus cause it in a considerable percentage of individuals who receive them (hydralazine hydrochloride, isoniazid, procainamide hydrochloride, and various anticonvulsants), and ...
Eugenia Fishbein +2 more
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Antinuclear antibodies in infectious diseases
Infectious Diseases, 2019Introduction: Antinuclear antibody (ANA) tests are widely used for the diagnosis of autoimmune diseases, but ANAs are also commonly found in patients with various infections. This retrospective study aimed to investigate the relationship between infections and ANA status.Methods: Patients that visited the Department of Infectious Diseases at Inha ...
Jae Hyoung Im +6 more
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Antinuclear Antibodies in Pleural Fluid
Chest, 1994Systemic lupus erythematosus (SLE) frequently involves the pleura with resultant pleural effusion. Previous studies have reported that detection of antinuclear antibodies (ANA) in pleural fluid using animal tissue as substrate was a sensitive and specific method for distinguishing SLE pleural effusions from other etiologies. The HEp-2 ANA, which uses a
G. Douglas Campbell +4 more
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ANTINUCLEAR ANTIBODIES IN INFECTIOUS MONONUCLEOSIS
The Lancet, 1968Abstract By an indirect immunofluorescence technique antinuclear antibodies were detected transiently, and in low concentrations, in the sera of fourteen of twenty-one patients with infectious mononucleosis. Antinuclear antibodies of both the IgG and IgM variety were encountered.
ManuelE. Kaplan, EngM. Tan
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2016
Autoantibodies are historical hallmarks in the establishment of the concept of autoimmunity and in the definition of the clinical limits of several autoimmune diseases. On a day-to-day basis, autoantibodies are helpful elements not only in the diagnosis of autoimmune diseases, but also frequently in the establishment of prognosis and in the monitoring ...
Wilson de Melo Cruvinel +3 more
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Autoantibodies are historical hallmarks in the establishment of the concept of autoimmunity and in the definition of the clinical limits of several autoimmune diseases. On a day-to-day basis, autoantibodies are helpful elements not only in the diagnosis of autoimmune diseases, but also frequently in the establishment of prognosis and in the monitoring ...
Wilson de Melo Cruvinel +3 more
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Enzyme Immunoassays for Antinuclear Antibodies
Clinics in Laboratory Medicine, 1997To evaluate the potential advantages and disadvantages of the EANA, the immunopathology laboratory of the Henry Ford Health System compared the qualitative and quantitative results from several EANA assays to those from a well-standardized FANA assay and then correlated them with the clinical data.
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