Results 111 to 120 of about 955,307 (300)

Pan-viral serology implicates enteroviruses in acute flaccid myelitis. [PDF]

, 2019
Since 2012, the United States of America has experienced a biennial spike in pediatric acute flaccid myelitis (AFM)1-6. Epidemiologic evidence suggests non-polio enteroviruses (EVs) are a potential etiology, yet EV RNA is rarely detected in cerebrospinal
Banerji, Debarko, Benson, Leslie, Bove, Riley, Briggs, Benjamin, Cheung, Carly K, Chitnis, Tanuja, Chiu, Charles Y, Chu, Victoria, Crawford, Emily D, DeRisi, Joseph L, Ding, Joy Z, Dominguez, Samuel R, Gelfand, Amy A, Glaser, Carol A, Gorman, Mark P, Hauser, Stephen L, Hawes, Isobel A, Johnson-Kerner, Bethany L, Khan, Lillian M, Konopka-Anstadt, Jennifer L, Krishnamoorthy, Kalpathy S, Lopez, Adriana S, Lyden, Amy, Marine, Rachel L, McMillan, Hugh J, Messacar, Kevin, Nash, Kendall, Ng, Terry Fei Fan, Nix, W Allan, O'Donovan, Brian D, Oberste, M Steven, Pak, John E, Ramachandran, Prashanth S, Ramesh, Akshaya, Sample, Hannah A, Schubert, Ryan D, Sit, Rene, Soldatos, Ariane, Sowa, Gavin M, Tan, Michelle, Tato, Cristina M, Wadford, Debra A, Wilson, Michael R, Wu, Wesley, Yen, Cynthia, Zorn, Kelsey C   +45 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

A broad antibody with enhanced HIV-1 neutralization via bispecific antibody-mediated prepositioning

Nature Communications
Antibodies targeting the highly conserved prehairpin intermediate (PHI) of class I viral membrane-fusion proteins are generally weakly neutralizing and are not considered viable therapeutic agents. We previously demonstrated that antibodies targeting the
Soohyun Kim, Caelan E. Radford, Duo Xu, Jianing Zhong, Jonathan Do, Dominic M. Pham, Katie A. Travisano, Maria V. Filsinger Interrante, Theodora U. J. Bruun, Valerie Rezek, Bailey Wilder, Martina Palomares, Michael S. Seaman, Scott G. Kitchen, Jesse D. Bloom, Peter S. Kim   +15 more
doaj   +1 more source

A gorilla adenovirus-based vaccine against Zika virus induces durable immunity and confers protection in pregnancy [PDF]

, 2019
The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla adenovirus-based ZIKV vaccines that encode for pre-membrane (prM) and envelope (E) proteins (GAd-Zvp ...
Brough, Douglas E, Curiel, David T, Diamond, Michael S, Dmitriev, Igor P, Fremont, Daved H, Hassan, Ahmed O, Kashentseva, Elena A, Zhao, Haiyan   +7 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Anti-neutrophil antibodies in chronic viral hepatitis

Journal of Hepatology, 1994
J ...
Dalekos, G. N., Tsianos, E. V.
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Topographical mapping of epitopes on the glycoproteins of murine hepatitis virus-4 (strain JHM): correlation with biological activities. [PDF]

, 1984
Monoclonal hybridoma antibodies (MAb) of defined polypeptide specificity and biological activity were used in a competition binding assay to identify antibody binding sites (epitopes) on the glycoproteins of murine hepatitis virus-4 strain JHM (MHV-4 ...
Buchmeier, MJ, Knobler, RL, Salmi, AA, Talbot, PJ   +3 more
core  

Life‐Threatening Bradycardia in Anti‐NMDA‐Receptor Encephalitis and a Novel Use for Permanent Pacing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pediatric anti‐NMDA receptor encephalitis (pNMDARE) is an autoantibody‐mediated disorder that can cause severe autonomic dysfunction, including symptomatic bradycardia and asystole. Dysautonomia can last for years, making it very challenging to manage.
Sarah Tucker, Abhijit Das, Andres Jimenez, Areeba Basit, Yike Jiang, Emily A. Smitherman, Heather Van Mater, Taylor Howard, Alexander J. Sandweiss, Kristen S. Fisher   +9 more
wiley   +1 more source