Results 211 to 220 of about 2,860,326 (352)

Using IgY for diagnosis of respiratory infections: practical application in COVID-19. [PDF]

Future Sci OA
Amaral CML, Pinto Júnior VC, Lima DF, da Costa HPS, Farias DAB, da Silva Neto JX, Moura LFWG, da Silva BB, Freitas ER, Van Tilburg MF, Guedes MIF.   +10 more
europepmc   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Current status of severe fever with thrombocytopenia syndrome in China (Review). [PDF]

Int J Mol Med
Sun H, Hu Q, Lu S, Yang Y, Zhang L, Long J, Jin Y, Yang H, Chen S, Duan G.   +9 more
europepmc   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future. [PDF]

Biochemistry
Subramaniam S, Saville JW, Feng F, Freiburger L.   +3 more
europepmc   +1 more source

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

Development of blood-brain barrier-penetrating antibodies for neutralizing tick-borne encephalitis virus in the brain. [PDF]

mSphere
Fukuta M, Fukano S, Maekawa N, Kobayashi S, Okamoto S, Hirano M, Nio-Kobayashi J, Kariwa H, Kawakami S, Konnai S, Yoshii K.   +10 more
europepmc   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery

Advanced Healthcare Materials, EarlyView.
Nanoparticle (NP) stiffness affects cellular uptake, but its impact on intracellular distribution remains unclear. This study synthesizes silica nanocapsules with varying stiffness, inspired by viral mechanisms, and applies assays to measure cellular uptake and escape efficiency.
Yali Zhang, Yue Hui, Zichao Guo, Dawei Liu, Yun Liu, Huajian Gao, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Discovery of a novel lymphocytic choriomeningitis virus strain associated with severe human disease in immunocompetent patient, New Mexico. [PDF]

Emerg Microbes Infect
Gass JT, Nofchissey RA, Twohig FM, Ye C, Goodfellow SM, Mentore K, Burgos M, Negrete O, Whitmer S, Klena JD, Cannon D, Sayyad L, Bradfute SB.   +12 more
europepmc   +1 more source

Viral Receptor-Binding Site Antibodies with Diverse Germline Origins

Cell, 2015
A. Schmidt, Matthew D. Therkelsen, Shaun Stewart, T. Kepler, H. Liao, M. A. Moody, B. Haynes, S. Harrison, S. Harrison   +8 more
semanticscholar   +1 more source