Results 161 to 170 of about 71,992 (213)

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial. [PDF]

Signal Transduct Target Ther
Yao H, Yan M, Tong Z, Wu X, Yin Y, Ryu MH, Park JJ, Jiang S, Kim JH, Wang S, Zhong Y, Voskoboynik M, Zhang J, Kaubisch A, Liu C, Chen Y, Im SA, Wu L, Liu Y, Ganju V, Barve M, Li H, Yao G, Yang M, Bao L, Zhao Y, Zhao J, Zhao K, Shen Y, Rong S, Zhu X, Song E.   +31 more
europepmc   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Efficacy and safety of antibody-drug conjugate combination therapy in advanced urothelial carcinoma. [PDF]

Front Oncol
Jaime-Casas S, Barragan-Carrillo R, Zugman M, Shah K, Ebrahimi H, Mercier B, Castro DV, Zang PD, LeVee A, Yip W, Li X, Dizman N, Salgia NJ, Zengin Z, Meza L, Hsu J, Nguyen CB, Chehrazi-Raffle A, Pal SK, Tripathi A.   +19 more
europepmc   +1 more source

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

Advanced Healthcare Materials, EarlyView.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli, Arianna Iacomino, Federico Serpe, Lucia Iafrate, Marco Bastioli, Giorgia Montalbano, Biagio Palmisano, Silvia Franco, Roberta Angelini, Alessandro Corsi, Mara Riminucci, Giancarlo Ruocco, Chiara Scognamiglio, Andrea Barbetta, Gianluca Cidonio   +14 more
wiley   +1 more source

Can Epithelial-Myoepithelial Carcinoma of the Breast Benefit from TROP2 Antibody-Drug Conjugate? [PDF]

Onco Targets Ther
Zhao Q, Luo X, Xing H, Jiang C, Ma J, Tang L.   +5 more
europepmc   +1 more source

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

Phenotypic discovery and therapeutic evaluation of an <i>ITGA3B1</i>-targeting antibody-drug conjugate for bladder cancer. [PDF]

Sci Adv
Lee J, Jung H, Kim EG, Ahn J, Haffner MC, Nelson PS, Kim KP, Lee JK, Yi EC, Kim KM.   +9 more
europepmc   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

State-of-the-Art Imaging in Antibody-Drug Conjugate Treatment for Advanced Bladder Cancer. [PDF]

Korean J Radiol
Eid S, Al-Yousef AS, Kim KW, Yoon S, Nawfal R, Bellmunt J, Choueiri TK, Krajewski KM.   +7 more
europepmc   +1 more source