Results 181 to 190 of about 71,992 (213)

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Leveraging artificial intelligence in antibody-drug conjugate development: from target identification to clinical translation in oncology. [PDF]

NPJ Precis Oncol
Lu Y, Huang W, Li Y, Xu Y, Wei Q, Sha C, Guo P.   +6 more
europepmc   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

Preclinical Characterization of XB010: A Novel Antibody-Drug Conjugate for the Treatment of Solid Tumors that Targets Tumor-Associated Antigen 5T4. [PDF]

Mol Cancer Ther
Mendelsohn BA, Gogas KR, Higaki JN, Solis WA, Vainshtein I, Cheng J, Park M, Hennessy MA, Janson CM, Matsuda Y, Barfield RM, Drake PM, Chuprakov S, Hickle CL, Linz T, Bauzon M, Yeo DY, Zhang F, Ogunkoya AO, Kantak S.   +19 more
europepmc   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

Advanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim, Ye‐Ji Kim, Seyoung Ryu, Daeui Park, Kyoung‐Sik Moon, Yu Bin Lee, Dong Ho Woo   +6 more
wiley   +1 more source

Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500. [PDF]

Bioconjug Chem
Lee HM, Abdul-Hadi K, Appleman VA, Cardin D, Dong L, England D, Ganno ML, Gershman R, Gigstad K, Gulavita N, Hu Z, Huang J, Huang SC, Lok D, Ma L, Malley J, Mizutani M, Molchanova N, Piatkov KI, Rice E, Shi Z, Vyskocil S, Wang J, Xu H, Xu T, Zhang DM, Zhang J, Abu-Yousif AO.   +27 more
europepmc   +1 more source

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Overcoming immunotherapy resistance in bladder cancer with a novel antibody-drug conjugate RC48. [PDF]

J Immunother Cancer
Xiao J, Liu J, Zhang C, Liu Z, Nie Z, Yi Z, Gao X, Liang H, Huang J, Cai Z, Yan L, Wu B, Liu Z, Chen J, Zu X, Hu J.   +15 more
europepmc   +1 more source

The Impact of Conjugation Mode and Site on Tubulysin Antibody-Drug-Conjugate Efficacy and Stability. [PDF]

ChemistryOpen
Yamazoe S, Cheng Q, Kotapati S, Rangan VS, Sung MC, Deshpande M, Jashnani A, Qiang C, Smith MJ, Pan C, Dollinger G, Rajpal A, Strop P, Rao C.   +13 more
europepmc   +1 more source