Results 21 to 30 of about 49,378 (218)
Nature CommunicationsHigh-sensitivity glycomic analysis is essential for advancing both basic and translational biomedical research, yet remains methodologically challenging for limited-quantity samples, primarily due to complex workflows and reliance on specialized ...
Nafisa Tursumamat +10 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Antibody–Drug Conjugates: The Last Decade
Pharmaceuticals, 2020 An armed antibody (antibody–drug conjugate or ADC) is a vectorized chemotherapy, which results from the grafting of a cytotoxic agent onto a monoclonal antibody via a judiciously constructed spacer arm.
Nicolas Joubert +3 more
doaj +1 more source
Antibody-Drug Conjugates in Solid Tumors
healthbook TIMES. Oncology Hematology, 2022 Solid tumors account for approximately 90% of all types of cancer. For many tumor types, the availability of effective treatment options is limited and new targeted approaches that offer the potential for long-term survival are warranted.
Ilaria Colombo, Alfred Zippelius
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Self-polymerized polyphenol-based platform for the management of dry eye pathogenesis
Nature CommunicationsThe management of ocular surface inflammation, particularly in conditions like dry eye disease (DED), remains challenging due to multiple pathogenic causes and ocular barriers.
Zixin Wang +6 more
doaj +1 more source
Experimental and Molecular Medicine, 2023 Within the tumor microenvironment (TME), regulatory T cells (Tregs) play a key role in suppressing anticancer immune responses; therefore, various strategies targeting Tregs are becoming important for tumor therapy.
Juwon Yang, Hyunsu Bae
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Antibody Drug Conjugates as Cancer Therapeutics
Antibodies, 2013 Monoclonal antibody (MAb) based therapies have achieved considerable success in oncology, primarily when used in combination with cytotoxic drugs. Antibody drug conjugates (ADCs) are a class of therapeutics that harness the antigen-selectivity of MAbs to
Pamela A. Trail
doaj +1 more source
Cutaneous Lymphoma and Antibody-Directed Therapies
Antibodies, 2023 The introduction of monoclonal antibodies such as rituximab to the treatment of cancer has greatly advanced the treatment scenario in onco-hematology. However, the response to these agents may be limited by insufficient efficacy or resistance.
Alvise Sernicola +3 more
doaj +1 more source