Multiple subsets of anti-tetanus toxoid antibody-producing cells in human peripheral blood differ by size, expression of membrane receptors, and mitogen reactivity. [PDF]
Carol J. Thiele +2 more
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Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source
The TNF-ligand APRIL can control CIA by regulating antibody-production and stimulating anti-inflammatory IL-10 producing B cells [PDF]
Leticia Fernández +9 more
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Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Evidence of macrophages being 19 S-antibody producing cells, as shown by a modification of the Plaque—Technique [PDF]
H Noltenius, Parker Ruhl
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We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima +4 more
wiley +1 more source
Inducible immortalized Dendritic Cells enable antigen-specific antibody production in a murine in vitro Immunization model. [PDF]
Egert J, Maier N, Micheel B, Hanack K.
europepmc +1 more source
Single Mouse Cells Producing Two Antibody Molecules and Giving Rise to Antigen-Driven Intraclonal Variation after Immunization with Two Unrelated Antigens [PDF]
Jacques Couderc +3 more
openalex +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source

