Results 111 to 120 of about 2,398,894 (298)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Drug-Resistance Mechanism and New Targeted Drugs and Treatments of Relapse and Refractory DLBCL

Cancer Management and Research, 2023
Jing Zhang, Yan Gu, Baoan Chen Department of Hematology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People’s Republic of ChinaCorrespondence: Baoan Chen, Department of Hematology, Zhongda Hospital, School of Medicine ...
Zhang J, Gu Y, Chen B
doaj  

Computational selection of antibody-drug conjugate targets for breast cancer

, 2015
The selection of therapeutic targets is a critical aspect of antibody-drug conjugate research and development. In this study, we applied computational methods to select candidate targets overexpressed in three major breast cancer subtypes as compared ...
Fauteux, Fran\ue7ois, Phan, Sieu, O'Connor-McCourt, Maureen, Pan, Youlian, Jaramillo, Maria L., Famili, Fazel, Hill, Jennifer J.   +6 more
core  

Supplementary Table S2 from Engineered anti-CD70 antibody-drug conjugate with increased therapeutic index

, 2008
Supplementary Table S2 from Engineered anti-CD70 antibody-drug conjugate with increased therapeutic ...
Eileen Turcott (15041066), Ivan Stone (15036102), Hans-Peter Gerber (4261570), Lori Westendorf (15036087), Charlotte F. McDonagh (14973178), Stephen C. Alley (1897735), Django Sussman (1934839), Martha Anderson (1934836), Paul J. Carter (3387371), Tiffany Feist (15036093), Jamie Miyamoto (15041069), Kristine M. Kim (15036084), Lindsay L. Brown (15036090), Robert Lyon (15036096)   +13 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Supplemental Figure Legend from Anti-Endosialin Antibody–Drug Conjugate: Potential in Sarcoma and Other Malignancies

, 2015
Supplemental Figure Legend from Anti-Endosialin Antibody–Drug Conjugate: Potential in Sarcoma and Other ...
Cecile Rouleau (14974161), Bruce C. Horten (15072706), Robert Smale (14974167), Stephanie D. Roth (15072697), Steven M. Schmid (15072709), Roy Krumbholz (328645), Kenneth J. Munroe (15072700), Jay Harper (203272), Tessa L. Green (15072703), Beverly A. Teicher (9030386), Diego A. Gianolio (1831690)   +10 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Corneal pseudomicrocysts following claudin-6 antibody-drug conjugate infusion

American Journal of Ophthalmology Case Reports
Purpose: To report a case of bilateral corneal pseudomicrocysts associated with infusions of a novel antibody-drug conjugate targeting claudin-6, called TORL-1-23.
Laura Matuszewska, Caitlynn Cooper, Victoria Sattarova, Wassef Chanbour, Evan Meyer, Vania Rashidi   +5 more
doaj   +1 more source

Antibody drug conjugates in urological cancers: A review of the current landscape

Our review delves into the progress across urological malignancies and discusses ongoing challenges and future directions in antibody-drug conjugate (ADC) development, emphasising their transformative potential in cancer care.
Rebuzzi, Sara E, Ghosh, Adheesh, Vasdev, Nikhil, Maniam, Akash, Banna, Giuseppe L, Lapitan, Patricia, Shinde, Sayali D, Basu, Sreejana, Ürün, Yüksel, Sharma, Anand, Kanesvaran, Ravindran, Apte, Vedika, Parkes, Jo, Ghose, Aruni, Das, Prantik, Kandala, Abhinav, Boussios, Stergios   +16 more
core   +1 more source