Results 241 to 250 of about 2,398,894 (298)

Antimetabolites synergize with non-genotoxic antibody drug conjugate conditioning in hematopoietic stem cell lentiviral gene therapy. [PDF]

Mol Ther Adv
Okalova J, Alexander JS, Patel SR, Branella GM, Barichello de Quevedo C, Baldwin WH, Prince C, Chandrakasan S, Brown HC, Doering CB, Spencer HT.   +10 more
europepmc   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

Targeting uPARAP with an Antibody-Drug Conjugate Exhibits Efficacy against Mesothelioma and Synergizes with Cisplatin. [PDF]

Cancer Res Commun
Çakılkaya P, Egeland Larsen IM, Jiang Q, Sandal Nørregaard K, Gårdsvoll H, Zhang J, Jürgensen HJ, Hansen Blomquist M, Martinez Perlado A, Krigslund O, Santoni-Rugiu E, Engelholm LH, Hassan R, Behrendt N.   +13 more
europepmc   +1 more source

Narrative review of the similarities and differences between immune checkpoint inhibitor- and antibody-drug conjugate-associated pneumonitis. [PDF]

Transl Lung Cancer Res
Tan R, Qian F, Zhang Y, Cao S, Zhong H.
europepmc   +1 more source

Payload Diversification Overcomes Resistance and Guides Sequential Antibody-Drug Conjugate Therapy in Breast Cancer. [PDF]

Clin Cancer Res
Rampa DR, Seo M, Ogata N, Yang Z, Sridhar N, Fujii T, Wannaphut C, Maynard JA, Tsuchikama K, Sledge GW, Ueno NT, Lee J.   +11 more
europepmc   +1 more source

HEV-Targeted Antibody-Drug Conjugate Promotes Long-Term Cardiac Allograft Acceptance. [PDF]

Circulation
Che Y, Yamamura Y, Jung S, Sabiu G, Kondengadan SM, Lucia SE, Song Y, Byun H, Li X, Seelam AJ, Yamamura M, Inoue Y, Zhao J, Madsen JC, Kasinath V, Uchimura K, Tsokos GC, Kim P, Bromberg JS, Abdi R.   +19 more
europepmc   +1 more source

Mislocalisation of FLT3-ITD receptor contributes to MV4-11 leukaemia cell resistance to antibody-drug conjugate. [PDF]

J Enzyme Inhib Med Chem
Nirachonkul W, Farrell MP, Tolbert TJ, Okonogi S, Tima S, Anuchapreeda S, Chiampanichayakul S, Siahaan TJ.   +7 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Antibody drug conjugates

Current Opinion in Oncology, 2014
Antibody conjugates are a diverse complex class of therapeutics, consisting of a potent cytotoxic agent linked covalently to an antibody or antibody fragment directed toward a specific cell surface target expressed by tumor cells or an extracellular target, that are having impact in the clinic.
BATT DAVID BRYANT, ETTENBERG SETH ALEXANDER, HAUBST NICOLE, HU TIANCEN, JENKINS DAVID, TOKSOZ ENGIN, PETROPOULOS KONSTANTIN, MEYER MATTHEW JOHN   +7 more
  +22 more sources

Antibody drug conjugates

Biotechnology Letters, 2016
Antibody drug conjugates (ADCs) have emerged as a viable option in targeted delivery of highly potent cytotoxic drugs in treatment of solid tumors. At the time of writing, only two ADCs have received regulatory approval with >40 others in clinical development. The first generation ADCs suffered from a lack of specificity in amino acid site-conjugations,
ABRAMS TINYA, COHEN STEVEN BRUCE, DAMIANO JASON, DÜRR CLEMENS, HUBER THOMAS, MENEZES DANIEL, MILLER KATHY, RENDAHL KATHERINE, RONDEAU JEAN-MICHEL RENE   +8 more
openaire   +7 more sources

Antibody-Conjugated Drug Assay for Protease-Cleavable Antibody–Drug Conjugates

Bioanalysis, 2015
Antibody-drug conjugates (ADCs) require multiple assays to characterize their PK. These assays can separately evaluate the ADC by quantifying the antibody or the conjugated drug and may give different answers due to assay measurement differences, heterogeneous nature of ADCs and potential biotransformations that occur in vivo.We present a new version ...
Russell J, Sanderson, Nicole D, Nicholas, Cassandra, Baker Lee, Shawna Mae, Hengel, Robert P, Lyon, Dennis R, Benjamin, Stephen C, Alley   +6 more
openaire   +2 more sources