Results 21 to 30 of about 2,398,894 (298)

Development of Photoremovable Linkers as a Novel Strategy to Improve the Pharmacokinetics of Drug Conjugates and Their Potential Application in Antibody–Drug Conjugates for Cancer Therapy

Pharmaceuticals, 2022
Although there have been extensive research and progress on the discovery of anticancer drug over the years, the application of these drugs as stand-alone therapy has been limited by their off-target toxicities, poor pharmacokinetic properties, and low ...
Audrey Nathania Johan, Yi Li
doaj   +1 more source

Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models

Communications Medicine, 2021
Lee et al. use an antibody-drug conjugate to treat pathologic ocular neovascularization in mouse models. The antibody-drug conjugate targets PDGFRβ-expressing pericytes, with similar therapeutic effects to an anti-VEGF agent and with limited unwanted ...
Seok Jae Lee, Soohyun Kim, Dong Hyun Jo, Chang Sik Cho, Su Ree Kim, Dongmin Kang, Jisu Chae, Duck Kyun Yoo, Suji Ha, Junho Chung, Jeong Hun Kim   +10 more
doaj   +1 more source

Supplementary Figure from Targeting a Radiosensitizing Antibody–Drug Conjugate to a Radiation-Inducible Antigen

, 2021
Supplementary Figure from Targeting a Radiosensitizing Antibody–Drug Conjugate to a Radiation-Inducible ...
Abhay K. Singh (15033101), Dennis E. Hallahan (10510788), Fong-Fu Hsu (256082), Dinesh Thotala (15033104), Vaishali Kapoor (15033107), Calvin D. Lewis (15033098)   +5 more
core   +4 more sources

Assembly of pH-Responsive Antibody-Inspired Protein-Drug Conjugates [PDF]

, 2021
With the advent of chemical strategies that allow the design of smart bioconjugates, peptide- and protein-drug conjugates are emerging as highly efficient therapeutics to overcome limitations of conventional treatment, as exemplified by antibody-drug ...
Seah Ling, Kuan, Michaela, Pieszka, Tao, Wang, Maksymilian Marek , Zegota, David Y. W. , Ng, Marco, Raabe, Tanja, Weil, Astrid , Heck, Lutz , Nuhn   +8 more
core   +2 more sources

Pneumococcal antibody concentrations and carriage of pneumococci more than 3 years after infant immunization with a pneumococcal conjugate vaccine. [PDF]

, 2012
BACKGROUND: A 9-valent pneumococcal conjugate vaccine (PCV-9), given in a 3-dose schedule, protected Gambian children against pneumococcal disease and reduced nasopharyngeal carriage of pneumococci of vaccine serotypes.
Greenwood, Brian M, Godwin C. Enwere, Brown J Okoko, Nsekpong, Ekpedeme D, Godwin C Enwere, Ekpedeme D Nsekpong, Syed M. A. Zaman, Aderonke A. Odutola, Saaka, Mark, Zaman, Syed MA, Akinsola, Adebayo K, Richard A. Adegbola, Syed M A Zaman, Adebayo K. Akinsola, Aderonke A Odutola, Richard A Adegbola, Martin O. C. Ota, Okoko, Brown J, Odutola, Aderonke A, Martin O C Ota, Cutts, Felicity T, Felicity T Cutts, Ekpedeme D. Nsekpong, Felicity T. Cutts, Adebayo K Akinsola, Brown J. Okoko, Enwere, Godwin C, Brian M Greenwood, Mark Saaka, Adegbola, Richard A, Brian M. Greenwood, Ota, Martin OC   +31 more
core   +1 more source

A disruptive clickable antibody design for the generation of antibody-drug conjugates

, 2023
298310Background: Antibody-drug conjugates are cancer therapeutics that combine specificity and toxicity. A highly cytotoxic drug is covalently attached to an antibody that directs it to cancer cells. The conjugation of the drug-linker to the antibody is
Miriam-Kousso Assi, Simon K Krebs, Stech, Marlitt, Rakotoarinoro, Nathanaël, Krebs, Simon, Nathanaël Rakotoarinoro, Yan F K Dyck, Maria K Parr, Dyck, Yan F.K., Parr, Maria K., Marlitt Stech, Assi, Miriam-Kousso   +11 more
core   +1 more source

"In vitro" and "in vivo" drug targeting using biotinylated immunoliposomes [PDF]

, 2005
The aim of my thesis was the optimization, characterization and application of a new, innovative drug carrier system which can be used to target pharmaceuticals to diseased tissues and organs.
Schnyder, Anita
core   +1 more source

A Trial of a 7-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults. [PDF]

, 2010
BACKGROUND: Streptococcus pneumoniae is a leading and serious coinfection in adults with human immunodeficiency virus (HIV) infection, particularly in Africa.
Zijlstra, EE, Molyneux, Malcolm E, White, Sarah A., Mwaiponya, Martin, Mwalukomo, Thandie, Gordon, Stephen, Zijlstra, Eduard E, Longwe, Herbert, French, N, Mwalukomo, T, White, SA, French, Neil, Gordon, SB, Mwaiponya, M, Gilks, CF, Gilks, Charles F, Mwafulirwa, Gershom, Molyneux, Malcolm E., Mwafulirwa, G, Molyneux, ME, Gordon, Stephen B., Gordon, Stephen B, White, Sarah; id_orcid, Longwe, H, Gilks, Charles F., White, Sarah A, Zijlstra, Eduard E.   +26 more
core   +1 more source

Pneumococcal serotype-specific antibodies persist through early childhood after infant immunization: follow-up from a randomized controlled trial [PDF]

, 2014
BACKGROUND: In a previous UK multi-center randomized study 278 children received three doses of 7-valent (PCV-7) or 13-valent (PCV-13) pneumococcal conjugate vaccine at 2, 4 and 12 months of age.
Trück, J, Yu, Ly-Mee, Finn, Adam, Ly-Mee Yu (44961), Pollard, Andrew J, Pollard Andrew J., Trück, Johannes; https://orcid.org/, Faust, Saul N, Johannes Trück, Merryn Voysey, Paul T. Heath (533551), Yu Ly-Mee, Voysey, M, Saul N. Faust (415924), Tatangeli, F, Andrew J Pollard, Voysey Merryn, Heath Paul T., Tatangeli, Florencia, Adam Finn (23223), Florencia Tatangeli (533550), Faust, S.N., Snape, MD, Pollard, AJ, Pollard, Andrew, Heath, PT, Adam Finn, Snape, Matthew, Merryn Voysey (255058), Faust Saul N., Andrew J. Pollard (44971), Snape Matthew D., Heath, Paul T, Voysey, Merryn, Yu, LM, Paul T Heath, Finn Adam, Tatangeli Florencia, Matthew D. Snape (533549), Faust, SN, Matthew D Snape, Finn, A, Snape, Matthew D, Florencia Tatangeli, Saul N Faust, Pollard, Andrew J., Ly-Mee Yu, Johannes Trück (533548), Truck, Johannes, Trück Johannes, Heath, Paul   +50 more
core   +1 more source

Emerging Pharmacotherapy for Relapsed or Refractory Hodgkins Lymphoma: Focus on Brentuximab Vedotin

Clinical Medicine Insights: Oncology, 2012
Hodgkins lymphoma (HL) which has relapsed post or is refractory to autologous bone marrow transplant presents an ongoing treatment challenge. Development of monoclonal antibodies (mAb) for the treatment of HL has aimed to replicate the success of mAb ...
Michelle Furtado, Simon Rule
doaj   +1 more source